Oogenesis articles within Nature

Featured

  • Article |

    Mouse induced pluripotent stem cells derived from differentiated fibroblasts could be converted from male (XY) to female (XX), resulting in cells that could form oocytes and give rise to offspring after fertilization.

    • Kenta Murakami
    • , Nobuhiko Hamazaki
    •  & Katsuhiko Hayashi

  • Article |

    Mass spectrometry and structural studies demonstrate the specific changes in protein composition that accompany the transition of ribosomes in zebrafish and Xenopus eggs from a dormant to an active state during early embryogenesis.

    • Friederike Leesch
    • , Laura Lorenzo-Orts
    •  & Andrea Pauli

  • Letter |

    The effect of vitamin C deprivation on mouse germline development is analysed, revealing that maternal vitamin C is required for proper DNA demethylation and the development of fetal oocytes, whereas the lack of vitamin C during pregnancy leads to reduced female fecundity in the offspring.

    • Stephanie P. DiTroia
    • , Michelle Percharde
    •  & Miguel Ramalho-Santos

  • Article |

    Analyses of insect eggs as well as genetic and life-history traits of insects show that where eggs are laid, rather than universal allometric constants, developmental rate or adult body size, underlies size and shape evolution.

    • Samuel H. Church
    • , Seth Donoughe
    •  & Cassandra G. Extavour

  • Letter |

    Using a protocol that recapitulates both meiosis and oocyte growth in vitro, the authors induce mouse pluripotent stem cells to differentiate into fully functional oocytes that can be fertilized and generate viable offspring, thereby recapitulating the full mammalian female germline cycle in a dish.

    • Orie Hikabe
    • , Nobuhiko Hamazaki
    •  & Katsuhiko Hayashi

  • Article |

    The egg receptor for Izumo, a sperm cell-surface protein required for male fertility, is identified here and renamed Juno; these findings show that the Izumo–Juno interaction is conserved within mammals, and open new opportunities for the development of fertility treatments and contraceptives.

    • Enrica Bianchi
    • , Brendan Doe
    •  & Gavin J. Wright

  • News & Views |

    Researchers have coaxed cultured embryonic stem cells to develop into eggs that then give rise to normal offspring. The discovery should help to decode the molecular basis of gamete formation and might lead to treatments for infertility.

    • Sihem Cheloufi
    •  & Konrad Hochedlinger

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