Featured
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Article |
Bacteria hijack a meningeal neuroimmune axis to facilitate brain invasion
Two Streptococcus spp. can utilize a neuropeptide (CGRP) and its receptor (RAMP1) on macrophages to promote brain invasion, a finding that may help the development of therapies for bacterial meningitis.
- Felipe A. Pinho-Ribeiro
- , Liwen Deng
- & Isaac M. Chiu
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Article |
Parallel ascending spinal pathways for affective touch and pain
Two populations of neurons with distinct anatomy and receptor expression that convey information from the spinal cord to the brain have different functional properties with respect to touch and pain.
- Seungwon Choi
- , Junichi Hachisuka
- & David D. Ginty
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Matters Arising |
Reply to: Heat detection by the TRPM2 ion channel
- Marie Mulier
- , Ine Vandewauw
- & Thomas Voets
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Letter |
Identifying the pathways required for coping behaviours associated with sustained pain
In mice, the ablation of spinal neurons that co-express TAC1 and LBX1 leads to the loss of coping responses to sustained pain without affecting reflexive defensive reactions to external threats.
- Tianwen Huang
- , Shing-Hong Lin
- & Qiufu Ma
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Article |
Structure-based discovery of opioid analgesics with reduced side effects
Computational docking to the the μ-opioid-receptor identifies PZM21, a novel selective biased agonist that generates substantial affective analgesia in mice without altering respiration or inducing drug reinforcement.
- Aashish Manglik
- , Henry Lin
- & Brian K. Shoichet
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Article |
Bacteria activate sensory neurons that modulate pain and inflammation
This study shows that most known mediators of immunity, such as TLR2, MyD88, T cells or B cells, and neutrophils and monocytes, are dispensable for pain produced by Staphylococcus aureus infection; instead, bacterial products, such as N-formylated peptides and α-haemolysin, induce pain by directly activating nociceptor neurons, which in turn modulate inflammation.
- Isaac M. Chiu
- , Balthasar A. Heesters
- & Clifford J. Woolf
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Letter |
Black mamba venom peptides target acid-sensing ion channels to abolish pain
A new class of peptides, mambalgins, is isolated from the African snake the black mamba, which can abolish pain through inhibition of particular subtypes of acid-sensing ion channels expressed either in central or peripheral neurons.
- Sylvie Diochot
- , Anne Baron
- & Eric Lingueglia
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News |
Rabbits show their pain
The extension of 'grimace scales' highlights their growing role in research.
- Daniel Cressey
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Article |
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
The crystal structure of the mouse μ-opioid receptor bound to an antagonist is described, with possible implications for the future development of analgesics.
- Aashish Manglik
- , Andrew C. Kruse
- & Sébastien Granier
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Letter |
A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain
- Christopher J. Bohlen
- , Alexander T. Chesler
- & David Julius
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Research Highlights |
Cognitive neuroscience: How self-touch relieves pain
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Research Highlights |
Neuroscience: No brain pain control
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Books & Arts |
Overcoming agony
A broad account of the science of pain offers hope to patients but highlights how the culture of medicine needs to change, explains Lucy Odling-Smee.
- Lucy Odling-Smee
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News |
Mouse pain study stirs debate
Canadian scientists vindicated after being accused of mistreating laboratory animals.
- Janelle Weaver
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News |
Mice pull pained expressions
Animal and human faces display similar responses to suffering.
- Janelle Weaver
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Gut enterochromaffin cells drive visceral pain and anxiety
Mice may make morphine
Calibrating the scales of suffering