Parasite development articles within Nature

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  • Article
    | Open Access

    A study describes the molecular basis of sexual development of Toxoplasma gondii entirely in vitro, demonstrating the role and interaction of AP2XII-1 and AP2XI-2 in the developmental program of this protozoan parasite.

    • Ana Vera Antunes
    • , Martina Shahinas
    •  & Mohamed-Ali Hakimi

  • Letter |

    Plasmodium parasites, the causative agent of malaria, infect and remodel red blood cells by exporting hundreds of proteins into the red blood cell cytosol, a topological conundrum given that the parasite resides in a compartment known as the parasitophorous vacuole; here a dihydrofolate-reductase-based destabilization domain approach is used to inactivate HSP101, part of the Plasmodium translocon of exported proteins, and to demonstrate that it is required for the secretion of all classes of exported Plasmodium proteins.

    • Josh R. Beck
    • , Vasant Muralidharan
    •  & Daniel E. Goldberg

  • Letter |

    Malaria parasites must produce gametocytes for transmission to the mosquito vector, although the molecular mechanisms underlying commitment to gametocyte production remain unclear; here this process is found to be controlled by PbAP2-G, a member of the ApiAP2 family of DNA-binding proteins, in the rodent-infecting Plasmodium berghei parasite.

    • Abhinav Sinha
    • , Katie R. Hughes
    •  & Andrew P. Waters

  • Letter |

    Here a genome-wide RNAi library screen is used to identify components of the signalling pathway that allow transformation of Trypanosoma brucei spp., the protozoan parasite responsible for important human and livestock diseases in sub-Saharan Africa, from proliferative slender forms to arrested stumpy forms which are transmitted to the tsetse fly vector.

    • Binny M. Mony
    • , Paula MacGregor
    •  & Keith Matthews

  • Letter |

    This study reports the identification of adult stem cells in the human parasite Schistosoma mansoni (blood fluke); the cells proliferate and differentiate into derivatives of multiple germ layers, and their maintenance requires a fibroblast growth factor receptor orthologue.

    • James J. Collins III
    • , Bo Wang
    •  & Phillip A. Newmark

  • Feature |

    It is 101 years since Carlos Chagas discovered the parasite responsible for the disease that now bears his name. What progress has been made since this discovery? Here Julie Clayton gives the low-down on Chagas disease.

    • Julie Clayton

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