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A transcriptional switch controls sex determination in Plasmodium falciparum
A non-genetic mechanism of sex determination in the human malaria parasite, Plasmodium falciparum, is described, and the male development 1 gene is identified as a potential target for interventions that block malaria transmission.
- A. R. Gomes
- , A. Marin-Menendez
- & A. M. Talman
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Article |
Structure and drug resistance of the Plasmodium falciparum transporter PfCRT
Structural, functional and in silico analyses of the chloroquine-resistance transporter PfCRT of Plasmodium falciparum suggest that distinct mechanistic features mediate the resistance to chloroquine and piperaquine in drug-resistant parasites.
- Jonathan Kim
- , Yong Zi Tan
- & Filippo Mancia
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Letter |
Single-cell RNA sequencing reveals a signature of sexual commitment in malaria parasites
Highly parallel single-cell transcriptome profiling of Plasmodium falciparum blood stages provides insight into the role AP2-G plays in early sexual development of this eukaryotic pathogen.
- Asaf Poran
- , Christopher Nötzel
- & Björn F. C. Kafsack
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Article |
A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis
The establishment of a drug-discovery screening pipeline for cryptosporidiosis, and identification of pyrazolopyridines as selective ATP-competitive inhibitors of the Cryptosporidium lipid kinase PI(4)K.
- Ujjini H. Manjunatha
- , Sumiti Vinayak
- & Thierry T. Diagana
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Letter |
Genetic modification of the diarrhoeal pathogen Cryptosporidium parvum
Cryptosporidium is an important cause of diarrhoeal disease in young children but until now it has been difficult to study; here, the parasite is genetically modified, paving the way for in-depth investigation and the development of effective treatments.
- Sumiti Vinayak
- , Mattie C. Pawlowic
- & Boris Striepen
Transcriptional control of the Cryptosporidium life cycle