Featured
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Letter |
Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’
- Helen S. Goodridge
- , Christopher N. Reyes
- & David M. Underhill
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Letter |
Unexpected requirement for ELMO1 in clearance of apoptotic germ cells in vivo
Cell death by apoptosis is crucial for tissue development and function, and occurs throughout life. Apoptotic cells must be cleared by phagocytic cells, but the mechanisms that regulate cell clearance in vivo remain unclear. Here, a conserved engulfment protein, ELMO1, is shown to be required for the phagocytic clearance of apoptotic germ cells by Sertoli cells in mouse testes. The findings make a compelling case for the relationship between engulfment and tissue homeostasis in vivo.
- Michael R. Elliott
- , Shuqiu Zheng
- & Kodi S. Ravichandran
Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein