Review Article |
Featured
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Article |
A phosphoinositide signalling pathway mediates rapid lysosomal repair
Lysosomal membrane damage triggers a lipid signalling pathway that repairs lysosomes via lipid transport at newly established endoplasmic reticulum–lysosomal membrane contact sites.
- Jay Xiaojun Tan
- & Toren Finkel
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Article |
Plasticity of ether lipids promotes ferroptosis susceptibility and evasion
The cellular organelles peroxisomes contribute to the sensitivity of cells to ferroptosis by synthesizing polyunsaturated ether phospholipids, and changes in the abundances of these lipids are associated with altered sensitivity to ferroptosis during cell-state transitions.
- Yilong Zou
- , Whitney S. Henry
- & Stuart L. Schreiber
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Article |
Structures of metabotropic GABAB receptor
Cryo-electron microscopy structures of heterodimeric and homodimeric full-length GABAB receptors, combined with cellular signalling assays, shed light on the mechanisms that underpin signal transduction mediated by these receptors.
- Makaía M. Papasergi-Scott
- , Michael J. Robertson
- & Georgios Skiniotis
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Article |
Lipid signalling drives proteolytic rewiring of mitochondria by YME1L
Under conditions such as hypoxia or starvation, an mTORC1-lipid signalling pathway initiates mitochondrial proteolysis by YME1L.
- Thomas MacVicar
- , Yohsuke Ohba
- & Thomas Langer
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Letter |
Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice
A single-chain variable fragment of the antibody E06, which binds to the phosphocholine headgroup of oxidized phospholipids, blocks the uptake of oxidized low-density lipoprotein by macrophages, and reduces inflammation and atherosclerosis in hypercholesterolaemic mice.
- Xuchu Que
- , Ming-Yow Hung
- & Joseph L. Witztum
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Letter |
A phosphoinositide conversion mechanism for exit from endosomes
A mechanism for phosphoinositide conversion at endosomes to enable exit from the endosomal system, suggesting that defective phosphoinositide conversion at endosomes underlies X-linked centronuclear myopathy.
- Katharina Ketel
- , Michael Krauss
- & Volker Haucke
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Letter |
Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid
Mfsd2a is the major transporter of the omega-3 fatty acid docosahexaenoic acid (DHA) into brain, with Mfsd2a-knockout mice showing reduced DHA in brain, neuronal cell loss in hippocampus and cerebellum, behavioural disorders and reduced brain size; DHA is transported in a sodium-dependent manner, in the form of lysophosphatidylcholines (LPCs) carrying long-chain fatty acids.
- Long N. Nguyen
- , Dongliang Ma
- & David L. Silver
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Letter |
Calcium-dependent phospholipid scrambling by TMEM16F
Lipid asymmetry can be disrupted during biological processes such as apoptosis, during which phosphatidylserine in the inner leaflet of the membrane is exposed on the outer membrane. It has been proposed that activation of a phospholipid scramblase catalyses bidirectional transbilayer movement of phospholipids, but the protein corresponding to this activity has not been identified. Here, the protein TMEM16F is identified, and is an essential component for the Ca2+-dependent exposure of phosphatidylserine on the plasma membrane. A patient with Scott syndrome, which results from a defect in phospholipid scrambling activity, was found to carry a mutation in the gene encoding TMEM16F.
- Jun Suzuki
- , Masato Umeda
- & Shigekazu Nagata
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Research Highlights |
Cell biology: Lung lipid hurts breathing