Pluripotency articles within Nature

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  • Article |

    An in vitro system that recapitulates temporal characteristics of embryonic development demonstrates that the different rates of mouse and human embryonic development stem from differences in metabolic rates and—further downstream—the global rate of protein synthesis.

    • Margarete Diaz-Cuadros
    • , Teemu P. Miettinen
    •  & Olivier Pourquié

  • Article |

    Primed pluripotent stem cells from distant species compete with each other, and inactivation of NF-κB signalling in normally outcompeted human cells improves their survival and chimerism in mouse embryos.

    • Canbin Zheng
    • , Yingying Hu
    •  & Jun Wu

  • Article |

    ERK reversibly regulates embryonic stem cell transcription via selective redistribution of co-factors and RNA polymerase from pluripotency to early differentiation enhancers, while leaving transcription factors bound to their enhancers, thus preserving plasticity.

    • William B. Hamilton
    • , Yaron Mosesson
    •  & Joshua M. Brickman

  • Letter |

    Exit of epiblasts from an unrestricted naive pluripotent state is required for epithelialization and generation of the pro-amniotic cavity in mouse embryos and for amniotic cavity formation in human embryos and human embryonic stem cells.

    • Marta N. Shahbazi
    • , Antonio Scialdone
    •  & Magdalena Zernicka-Goetz

  • Letter |

    Inhibition of mechanistic target of rapamycin (mTOR) suspends mouse blastocyst development and the cells remain ‘paused’ in a reversible pluripotent state, allowing prolonged culture.

    • Aydan Bulut-Karslioglu
    • , Steffen Biechele
    •  & Miguel Ramalho-Santos

  • Article |

    Using a single-cell sequencing analysis in monkey embryos, and comparing the genes expressed during early development in this species with those in mice and in human pluripotent stem cells, the authors define characteristics of pluripotency ontogeny across mammalian species.

    • Tomonori Nakamura
    • , Ikuhiro Okamoto
    •  & Mitinori Saitou

  • Letter |

    In mouse embryonic stem cells converted to an epiblast fate in vitro—a state in which the cells can also gain germ cell fate if exposed to the signalling molecule BMP4—the sole expression of the transcription factor NANOG is shown to be sufficient to induce germ cell fate, in the absence of BMP4.

    • Kazuhiro Murakami
    • , Ufuk Günesdogan
    •  & M. Azim Surani

  • Article |

    This study investigates how zygotic transcription is initiated and the maternal transcripts cleared in the zebrafish embryo: using loss-of-function analyses, high-throughput transcriptome sequencing and ribosome footprinting, the important roles of pluripotency factors Nanog, Pou5f1 and SoxB1 during these processes are identified.

    • Miler T. Lee
    • , Ashley R. Bonneau
    •  & Antonio J. Giraldez

  • News |

    Researchers awarded prestigious prize for their work on reprogramming mature cells to a pluripotent state.

    • Alison Abbott

  • News & Views |

    The transformation of skin cells into stem cells is a fascinating but poorly understood process. At last, the molecular characters underlying the initial steps have been revealed. See Letter p.652

    • Kyle M. Loh
    •  & Bing Lim

  • Article |

    A rare cell subpopulation within mouse embryonic stem cell cultures is identified that exhibits properties of two-cell (2C) embryos; the interconversion of ES cells to 2C cells correlates with endogenous retroviral activity.

    • Todd S. Macfarlan
    • , Wesley D. Gifford
    •  & Samuel L. Pfaff

  • Letter |

    Reprogramming of X-chromosome inactivation during the acquisition of pluripotency is accompanied by repression of Xist, the trigger of X-inactivation, and by upregulation of its antisense counterpart, Tsix. In undifferentiated embryonic stem cells (ESCs), key transcription factors that support pluripotency repress Xist transcription. These authors show that upregulation of Tsix in ESCs depends on a different subset of pluripotency factors. Therefore, two distinct ESC-specific complexes couple reprogramming of X-inactivation to pluripotency.

    • Pablo Navarro
    • , Andrew Oldfield
    •  & Philip Avner

  • Article |

    Pluripotent stem cells can be generated in the laboratory through somatic cell nuclear transfer (generating nuclear transfer embryonic stem cells, ntESCs) or transcription-factor-based reprogramming (producing induced pluripotent stem cells, iPSCs). These methods reset the methylation signature of the genome — but to what extent? Here it is found that mouse iPSCs 'remember' the methylation status of their tissue of origin, but the methylation of ntESCs is more similar to that of naturally produced ES cells.

    • K. Kim
    • , A. Doi
    •  & G. Q. Daley

  • Letter |

    To study the changes in chromatin structure that accompany zygotic genome activation and pluripotency during the maternal–zygotic transition (MZT), the genomic locations of histone H3 modifications and RNA polymerase II have been mapped during this transition in zebrafish embryos. H3 lysine 27 trimethylation and H3 lysine 4 trimethylation are only detected after MZT; evidence is provided that the bivalent chromatin domains found in cultured embryonic stem cells also exist in embryos.

    • Nadine L. Vastenhouw
    • , Yong Zhang
    •  & Alexander F. Schier

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