PolyADP-ribosylation articles within Nature

Featured

• Article
  23 November 2022 | Open Access

  Structural basis of tankyrase activation by polymerization

  Structural insights into the poly-ADP-ribosyltransferase tankyrase reveal its filamentous architecture and illustrate how assembly controls catalytic and non-catalytic functions.

  • Nisha Pillay
  • , Laura Mariotti
  •  & Sebastian Guettler

• Article | 06 February 2020

  HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation

  Assembly of a catalytic centre formed by HPF1 bound to PARP1 or PARP2 is essential for protein ADP-ribosylation after DNA damage in human cells.

  • Marcin J. Suskiewicz
  • , Florian Zobel
  •  & Ivan Ahel

• Letter | 19 October 2014

  Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal

  Structural and biochemical approaches are used to show how RNF146 activity is allosterically regulated by the binding of poly(ADP-ribose) ligand, and how substrate specificity is achieved with protein poly(ADP-ribosyl)ation and ubiquitination occurring in the same protein complex.

  • Paul A. DaRosa
  • , Zhizhi Wang
  •  & Wenqing Xu