Pre-diabetes articles within Nature

Featured

• Article
  30 August 2023 | Open Access

  Gut microbial carbohydrate metabolism contributes to insulin resistance

  Faecal carbohydrates, particularly host-accessible monosaccharides, are increased in individuals with insulin resistance and are associated with microbial carbohydrate metabolisms and host inflammatory cytokines.

  • Tadashi Takeuchi
  • , Tetsuya Kubota
  •  & Hiroshi Ohno

• Article | 18 May 2022

  Maternal inheritance of glucose intolerance via oocyte TET3 insufficiency

  Pregestational hyperglycaemia in mothers increases the probability of glucose intolerance in the offspring, an effect controlled by TET3-dependent DNA demethylation of genes involved in insulin secretion.

  • Bin Chen
  • , Ya-Rui Du
  •  & Hefeng Huang

• Article | 25 December 2019

  GDF15 mediates the effects of metformin on body weight and energy balance

  In mouse studies, metformin treatment results in increased secretion of growth/differentiation factor 15 (GDF15), which prevents weight gain in response to high-fat diet, and GDF15-independent lowering of circulating blood glucose.

  • Anthony P. Coll
  • , Michael Chen
  •  & Stephen O’Rahilly

• Article
  29 May 2019 | Open Access

  Longitudinal multi-omics of host–microbe dynamics in prediabetes

  Deep profiling of transcriptomes, metabolomes, cytokines, and proteomes, alongside changes in the microbiome, in samples from individuals with and without prediabetes reveal insights into inter-individual variability and associations between changes in the microbiome and other factors.

  • Wenyu Zhou
  • , M. Reza Sailani
  •  & Michael Snyder