Featured
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Top-down control of flight by a non-canonical cortico-amygdala pathway
This study describes a projection from the medial prefrontal cortex to the central amygdala that is involved in the regulation of defensive responses to threat.
- Chandrashekhar D. Borkar
- , Claire E. Stelly
- & Jonathan P. Fadok
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Article |
Dynamical prefrontal population coding during defensive behaviours
Dorsomedial prefrontal cortex represents threat and defensive action initiation, and the dynamic interplay between those representations dictates the temporal evolution of avoidance response to threats.
- Daniel Jercog
- , Nanci Winke
- & Cyril Herry
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Research Highlights |
A smart hub in the brain
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Letter |
Temporal dynamics and genetic control of transcription in the human prefrontal cortex
- Carlo Colantuoni
- , Barbara K. Lipska
- & Joel E. Kleinman
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Letter |
Neuronal basis of age-related working memory decline
- Min Wang
- , Nao J. Gamo
- & Amy F. T. Arnsten
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Research Highlights |
Omega-3s affect brain signalling
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Research Highlights |
Neuroscience: Instant learning
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Letter |
Impaired hippocampal–prefrontal synchrony in a genetic mouse model of schizophrenia
A deletion on human chromosome 22 (22q11.2) is one of the largest genetic risk factors for schizophrenia. Mice with a corresponding deletion have problems with working memory, one feature of schizophrenia. It is now found that these mice also show disruptions in synchronous firing between neurons of the prefrontal cortex and of the hippocampus, an electrophysiological phenomenon that has been linked to learning and memory and which is also thought to be disrupted in schizophrenia patients.
- Torfi Sigurdsson
- , Kimberly L. Stark
- & Joshua A. Gordon
A distinct cortical code for socially learned threat