Process chemistry articles within Nature

Featured

• Article | 16 March 2022

  A kinase-cGAS cascade to synthesize a therapeutic STING activator

  Leveraging enzymatic selectivity, a single reaction stream provides a single diastereomer of the cyclic dinucleotide MK-1454, a promising immune-oncology drug candidate, without the use of protecting groups or chiral auxiliaries.

  • John A. McIntosh
  • , Zhijian Liu
  •  & Matthew L. Maddess

• Article
  10 November 2021 | Open Access

  In situ formation of ZnO_x species for efficient propane dehydrogenation

  Propene is obtained through propane dehydrogenation using catalysts that are toxic, expensive or demanding to regenerate with ecologically harmful compounds, but the ZnO-based alternative reported here is cheap, clean and scalable.

  • Dan Zhao
  • , Xinxin Tian
  •  & Evgenii V. Kondratenko

• Article | 03 February 2021

  Bayesian reaction optimization as a tool for chemical synthesis

  Bayesian optimization is applied in chemical synthesis towards the optimization of various organic reactions and is found to outperform scientists in both average optimization efficiency and consistency.

  • Benjamin J. Shields
  • , Jason Stevens
  •  & Abigail G. Doyle

• Perspective | 12 June 2019

  The digitization of organic synthesis

  This Perspective discusses the challenges associated with the prediction of chemical synthesis, in particular the reaction conditions required for organic transformations, and the role of machine-learning approaches in the prediction process.

  • Ian W. Davies