Prognostic markers articles within Nature

Featured

• Article
  06 December 2023 | Open Access

  Organ aging signatures in the plasma proteome track health and disease

  Blood plasma protein data was combined with machine learning models for a simple method to determine differences in organ-specific aging; the study provides a basis for the prediction of diseases and aging effects using plasma proteomics.

  • Hamilton Se-Hwee Oh
  • , Jarod Rutledge
  •  & Tony Wyss-Coray

• Article
  20 September 2023 | Open Access

  Cingulate dynamics track depression recovery with deep brain stimulation

  This study demonstrates how activity in the cingulate cortex tracks depression recovery, providing symptom relief using deep brain stimulation.

  • Sankaraleengam Alagapan
  • , Ki Sueng Choi
  •  & Christopher J. Rozell

• Perspective | 12 July 2023

  Practical recommendations for using ctDNA in clinical decision making

  This Perspective reviews the utility and interpretation of circulating tumour DNA for the detection of residual and recurrent cancers and provides recommendations regarding its clinical application for a variety of solid tumours.

  • Stacey A. Cohen
  • , Minetta C. Liu
  •  & Alexey Aleshin

• Article | 08 September 2021

  A lymphocyte–microglia–astrocyte axis in chronic active multiple sclerosis

  Single-nucleus transcriptomics defines a diverse set of immune and glial cells at the chronically inflamed leading edge of demyelinated white matter lesions in patients with multiple sclerosis.

  • Martina Absinta
  • , Dragan Maric
  •  & Daniel S. Reich

• Article | 15 January 2020

  B cells and tertiary lymphoid structures promote immunotherapy response

  Multiomic profiling of several cohorts of patients treated with immune checkpoint blockade highlights the presence and potential role of B cells and tertiary lymphoid structures in promoting therapy response.

  • Beth A. Helmink
  • , Sangeetha M. Reddy
  •  & Jennifer A. Wargo

• Article | 15 January 2020

  B cells are associated with survival and immunotherapy response in sarcoma

  Immune profiling of the tumour microenvironment of soft-tissue sarcoma identifies a group of patients with high levels of B-cell infiltration and tertiary lymphoid structures that have improved survival and a high response rate to immune checkpoint blockade therapy.

  • Florent Petitprez
  • , Aurélien de Reyniès
  •  & Wolf H. Fridman

• Review Article | 18 December 2019

  Why and where an HIV cure is needed and how it might be achieved

  Current barriers and limitations to HIV treatments are reviewed, and suggestions for future steps to achieve an effective curative intervention are discussed.

  • Thumbi Ndung’u
  • , Joseph M. McCune
  •  & Steven G. Deeks

• Article
  29 May 2019 | Open Access

  Longitudinal multi-omics of host–microbe dynamics in prediabetes

  Deep profiling of transcriptomes, metabolomes, cytokines, and proteomes, alongside changes in the microbiome, in samples from individuals with and without prediabetes reveal insights into inter-individual variability and associations between changes in the microbiome and other factors.

  • Wenyu Zhou
  • , M. Reza Sailani
  •  & Michael Snyder

• Article | 09 January 2017

  Genomic hallmarks of localized, non-indolent prostate cancer

  Genomic analyses of localized, non-indolent prostate cancer identify recurrent aberrations that can predict relapse, and also highlight differences between early prostate cancer and metastatic, castration-resistant disease.

  • Michael Fraser
  • , Veronica Y. Sabelnykova
  •  & Paul C. Boutros

• Letter | 07 December 2016

  A 17-gene stemness score for rapid determination of risk in acute leukaemia

  A rapid gene signature test (LSC17) that captures stem cell expression programs in acute myeloid leukaemia patients at diagnosis is associated with therapy response and survival, facilitating initial treatment stratification.

  • Stanley W. K. Ng
  • , Amanda Mitchell
  •  & Jean C. Y. Wang

• Article | 24 June 2015

  Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

  Glypican-1 identifies cancer exosomes and serves as a biomarker for detection of early pancreatic cancer in patients and mouse models of the disease; the findings may enable early and non-invasive identification, and prevention of malignant cancer.

  • Sonia A. Melo
  • , Linda B. Luecke
  •  & Raghu Kalluri

• Letter | 28 January 2015

  EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors

  A subset of lung cancer cells with EGFR or BRG1 mutations shows selective sensitivity to a combination of EZH2 inhibitors with topoisomerase II inhibitors such as the commonly used chemotherapeutic drug etoposide.

  • Christine M. Fillmore
  • , Chunxiao Xu
  •  & Carla F. Kim

• Letter | 02 March 2011

  Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

  • Ingrid E. Wertz
  • , Saritha Kusam
  •  & Vishva M. Dixit

• Research Highlights | 30 June 2010

  Cancer genomics: Prognostic sign