Protein sequence analyses articles within Nature

Featured

• Letter | 21 June 2017

  Identifying specificity groups in the T cell receptor repertoire

  The authors devise an algorithm that can cluster T cell receptor (TCR) sequences sharing the same specificity, predict the HLA restriction of these TCR clusters on the basis of subjects’ genotypes and help to identify specific peptide major histocompatibility complex ligands.

  • Jacob Glanville
  • , Huang Huang
  •  & Mark M. Davis

• Letter | 19 May 2010

  Sequence space and the ongoing expansion of the protein universe

  The need to maintain the structural and functional integrity of an evolving protein limits the range of acceptable amino-acid substitutions — but to what extent does this constrain how far homologous protein sequences can diverge? Here, sequence divergence data are used to explore the limits of protein evolution, and to conclude that ancient proteins are continuing to diverge from one another, indicating that the protein sequence universe is slowly expanding.

  • Inna S. Povolotskaya
  •  & Fyodor A. Kondrashov