Restriction factors articles within Nature

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  • Article
    | Open Access

    The authors report the cryo-EM structure of human A3G bound to HIV-1 Vif, and the hijacked cellular proteins that promote ubiquitin-mediated proteolysis, suggesting how Vif antagonizes A3G by intercepting it to prevent viral restriction.

    • Yen-Li Li
    • , Caroline A. Langley
    •  & John D. Gross

  • Article |

    The transmembrane proteins SERINC3 and SERINC5 are identified as new restriction factors for HIV-1 replication; this restriction is counteracted by Nef and glycoGag, which prevent SERINC3 and SERINC5 from becoming incorporated into HIV-1 virions and from profoundly blocking HIV-1 infectivity, suggesting a potential new therapeutic strategy for immunodeficiency viruses.

    • Yoshiko Usami
    • , Yuanfei Wu
    •  & Heinrich G. Göttlinger

  • Article |

    The transmembrane protein SERINC5 is identified as a potent inhibitor of HIV-1 particle infectivity that is counteracted by Nef; Nef redirects SERINC5 from the plasma membrane to a Rab7-positive endosomal compartment, thus excluding it from HIV-1 particles, emphasizing the potential of SERINC5 as a potent anti-retroviral factor.

    • Annachiara Rosa
    • , Ajit Chande
    •  & Massimo Pizzato

  • Letter |

    MX2 is shown to be an interferon-induced inhibitor of HIV-1 infection, and this antiviral activity may involve the inhibition of nuclear import of subviral complexes.

    • Melissa Kane
    • , Shalini S. Yadav
    •  & Paul D. Bieniasz

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