SARS virus articles within Nature

Featured

  • Article |

    Infection with SARS-CoV-2 in rhesus macaques causes a respiratory disease that recapitulates aspects of COVID-19 in humans, establishing this species as an animal model for investigating the pathogenesis of SARS-CoV-2.

    • Vincent J. Munster
    • , Friederike Feldmann
    •  & Emmie de Wit

  • Article |

    Infection with SARS-CoV-2 causes interstitial pneumonia and viral replication in the lungs of transgenic mice that express a human version of ACE2, confirming the pathogenicity of the virus in this model.

    • Linlin Bao
    • , Wei Deng
    •  & Chuan Qin

  • Article |

    A newly identified coronavirus found in Malayan pangolins shares considerable sequence identity with SARS-CoV-2, which suggests that the latter may have originated from a recombination event involving SARS-related coronaviruses from bats and pangolins.

    • Kangpeng Xiao
    • , Junqiong Zhai
    •  & Yongyi Shen

  • Article |

    A yeast-based synthetic genomics platform is used to reconstruct and characterize large RNA viruses from synthetic DNA fragments; this technique will facilitate the rapid analysis of RNA viruses, such as SARS-CoV-2, during an outbreak.

    • Tran Thi Nhu Thao
    • , Fabien Labroussaa
    •  & Volker Thiel

  • Article |

    The crystal structure of the receptor-binding domain of the SARS-CoV-2 spike in complex with human ACE2, compared with the receptor-binding domain of SARS-CoV, sheds light on the structural features that increase its binding affinity to ACE2.

    • Jian Shang
    • , Gang Ye
    •  & Fang Li

  • Letter |

    A 4.0 Å resolution cryo-electron microscopy structure of the pre-fusion form of the trimeric spike from the human coronavirus HKU1 provides insight into how the spike protein mediates host-cell attachment and membrane fusion.

    • Robert N. Kirchdoerfer
    • , Christopher A. Cottrell
    •  & Andrew B. Ward

  • Letter |

    Whole-genome sequences of two novel SARS-CoV-related bat coronaviruses, in addition to a live isolate of a bat SARS-like coronavirus, are reported; the live isolate can infect human cells using ACE2, providing the strongest evidence to date that Chinese horseshoe bats are natural reservoirs of SARS-CoV.

    • Xing-Yi Ge
    • , Jia-Lu Li
    •  & Zheng-Li Shi

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