Screening articles within Nature

Featured

• Article | 20 March 2024

  Proteome-scale discovery of protein degradation and stabilization effectors

  A synthetic proteome-scale strategy enables the identification of a diverse range of human proteins that can induce the degradation or stabilization of a target protein in a proximity-dependent way.

  • Juline Poirson
  • , Hanna Cho
  •  & Mikko Taipale

• Article | 30 October 2019

  Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds

  Compounds that interact with mutant huntingtin and an autophagosomal protein are able to reduce cellular levels of mutant huntingtin by targeting it for autophagic degradation, demonstrating an approach that may have potential for treating proteopathies.

  • Zhaoyang Li
  • , Cen Wang
  •  & Boxun Lu