Featured
-
-
Article
| Open AccessApoptotic stress causes mtDNA release during senescence and drives the SASP
During senescence, minority mitochondrial outer membrane permeabilization leads to the release of mtDNA into the cytosol through BAX and BAK macropores, in turn activating the cGAS–STING pathway, a major regulator of the senescence-associated secretory phenotype.
- Stella Victorelli
- , Hanna Salmonowicz
- & João F. Passos
-
Article |
Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice
Mice overexpressing Has2 from the naked mole-rat showed an increase in hyaluronan levels in several tissues, and a lower incidence of spontaneous and induced cancer, attenuated inflammation through several pathways, extended lifespan and improved healthspan.
- Zhihui Zhang
- , Xiao Tian
- & Vera Gorbunova
-
Article
| Open AccessSignalling by senescent melanocytes hyperactivates hair growth
Senescent melanocytes of skin nevi drive hyperactivation of hair growth through the signalling factor SPP1.
- Xiaojie Wang
- , Raul Ramos
- & Maksim V. Plikus
-
Article |
Functional T cells are capable of supernumerary cell division and longevity
Through iterative cycles of viral challenge and rechallenge over ten years, mouse T cells are demonstrated to have essentially infinite potential for population expansion and longevity without malignant transformation or loss of functional competence.
- Andrew G. Soerens
- , Marco Künzli
- & David Masopust
-
Article
| Open AccessSenescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration
A lifetime cartography of in vivo senescent cells shows that they are heterogeneous. Senescent cells create an aged-like inflamed niche that mirrors inflammation associated with ageing and arrests stem cell proliferation and tissue regeneration.
- Victoria Moiseeva
- , Andrés Cisneros
- & Pura Muñoz-Cánoves
-
Article |
Blocking PD-L1–PD-1 improves senescence surveillance and ageing phenotypes
PD-L1 expression by senescent cells renders them resistant to clearance by CD8 T cells, suggesting PD-L1 as a target for mitigating the effects of ageing.
- Teh-Wei Wang
- , Yoshikazu Johmura
- & Makoto Nakanishi
-
Article |
Virus-induced senescence is a driver and therapeutic target in COVID-19
Virus-induced senescence is a central pathogenic feature in COVID-19, and senolytics, which promote apoptosis of senescent cells, can reduce disease severity in hamsters,mice, as well as humans infected with SARS-CoV-2.
- Soyoung Lee
- , Yong Yu
- & Clemens A. Schmitt
-
Review Article |
The role of retrotransposable elements in ageing and age-associated diseases
This Review discusses how the activity of retrotransposons influences ageing and the role of these mobile genetic elements in age-related diseases and their treatment.
- Vera Gorbunova
- , Andrei Seluanov
- & John M. Sedivy
-
Review Article |
The central role of DNA damage in the ageing process
This Review examines the evidence showing that DNA damage is associated with ageing phenotypes, suggesting that it may have a central role as the cause of ageing.
- Björn Schumacher
- , Joris Pothof
- & Jan H. J. Hoeijmakers
-
Article |
Senolytic CAR T cells reverse senescence-associated pathologies
Chimeric antigen receptor (CAR) T cells targeting uPAR, a cell-surface protein that is upregulated on senescent cells, eliminate senescent cells in vitro and in vivo and reduce liver fibrosis in mice.
- Corina Amor
- , Judith Feucht
- & Scott W. Lowe
-
Article |
L1 drives IFN in senescent cells and promotes age-associated inflammation
During cellular senescence in human and mouse cells, L1 transposons become transcriptionally derepressed and trigger a type-1 interferon response, which contributes to age-associated inflammation and age-related phenotypes.
- Marco De Cecco
- , Takahiro Ito
- & John M. Sedivy
-
Letter |
Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline
In a mouse model of tau-dependent neurodegenerative disease, the clearance of senescent glial cells prevents the degeneration of cortical and hippocampal neurons and preserves cognitive function.
- Tyler J. Bussian
- , Asef Aziz
- & Darren J. Baker
-
Letter |
SIRT6 deficiency results in developmental retardation in cynomolgus monkeys
A cynomolgus monkey model deficient in SIRT6 protein exhibits severe retardation in prenatal development, in which neuronal differentiation is delayed by activation of the H19 long non-coding RNA.
- Weiqi Zhang
- , Haifeng Wan
- & Baoyang Hu
-
Letter |
Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence
REV-ERBs, nuclear hormone receptors that regulate transcription as part of the circadian clock cell machinery, inhibit autophagy and lipogenesis in premalignant and malignant cells and impair tumour growth in vivo.
- Gabriele Sulli
- , Amy Rommel
- & Satchidananda Panda
-
Letter |
Senescence-associated reprogramming promotes cancer stemness
Cellular senescence induced by chemotherapy leads to the acquisition of stemness in cancer cells, which results in enhanced tumour-promoting capacity after forced release or spontaneous escape from the senescent cell-cycle arrest.
- Maja Milanovic
- , Dorothy N. Y. Fan
- & Clemens A. Schmitt
-
Letter |
Cytoplasmic chromatin triggers inflammation in senescence and cancer
Cytoplasmic chromatin activates the innate immunity cytosolic DNA-sensing cGAS–STING pathway, leading both to short-term inflammation to restrain activated oncogenes and to chronic inflammation that associates with tissue destruction and cancer.
- Zhixun Dou
- , Kanad Ghosh
- & Shelley L. Berger
-
Brief Communications Arising |
Lifespan effects of mitochondrial mutations
- Misa Hirose
- , Paul Schilf
- & Saleh M. Ibrahim
-
Article |
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
When senescent cells accumulate during adulthood they negatively influence lifespan and promote age-dependent changes in several organs; clearance of these cells delayed tumorigenesis in mice and attenuated age-related deterioration of several organs without overt side effects, suggesting that the therapeutic removal of senescent cells may be able to extend healthy lifespan.
- Darren J. Baker
- , Bennett G. Childs
- & Jan M. van Deursen
-
Article |
Autophagy maintains stemness by preventing senescence
The regenerative properties of muscle stem cells decline with age as the stem cells enter an irreversible state of senescence; a study of mouse muscle stem cells reveals that entry into senescence is an autophagy-dependent process and promoting autophagy in old satellite cells can reverse senescence and restore their regenerative properties in an injury model.
- Laura García-Prat
- , Marta Martínez-Vicente
- & Pura Muñoz-Cánoves
-
Letter |
Autophagy mediates degradation of nuclear lamina
In response to cancer-associated stress, autophagy machinery mediates degradation of nuclear lamina components in mammals, suggesting that cells might degrade nuclear components to prevent tumorigenesis.
- Zhixun Dou
- , Caiyue Xu
- & Shelley L. Berger
-
Letter |
Neutrophil ageing is regulated by the microbiome
Neutrophil ageing, which encourages inflammation and vaso-occlusion in a mouse model of sickle-cell disease, is shown to depend on the intestinal microbiota and activation of the TLR/Myd88 signalling pathways.
- Dachuan Zhang
- , Grace Chen
- & Paul S. Frenette
-
Review Article |
The role of senescent cells in ageing
Cellular senescence has recently been shown to have roles in complex biological processes other than protection against cancer, and to represent a series of progressive and diverse cellular states after initial growth arrest; better understanding of mechanisms underlying its progression and of acute and chronic senescent cells may lead to new therapeutic strategies for age-related pathologies.
- Jan M. van Deursen
-
Article |
Geriatric muscle stem cells switch reversible quiescence into senescence
This study shows that ageing satellite cells undergo an irreversible transition from a quiescent to a pre-senescent state that results in the loss of muscle regeneration in sarcopenia; furthermore, increased expression of p16INK4a is identified as a common feature of senescent satellite cells.
- Pedro Sousa-Victor
- , Susana Gutarra
- & Pura Muñoz-Cánoves
-
Letter |
A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence
Pyruvate dehydrogenase (PDH) is identified as a crucial mediator of BRAFV600E-induced cellular senescence: PDH is activated by BRAF-mediated suppression of PDK1, enhancing oxidative glucose metabolism, and PDK1 depletion eradicates mutant BRAF melanomas, indicating that this relationship between cell senescence and metabolism might be exploited therapeutically.
- Joanna Kaplon
- , Liang Zheng
- & Daniel S. Peeper
-
Outlook |
Cognition: The brain's decline
Treating cognitive problems common in elderly people requires a deeper understanding of how a healthy brain ages.
- Alison Abbott
-
Outlook |
Interventions: Live long and prosper
Researchers are learning about the molecular basis of ageing — and finding clues about how to treat diseases in the process.
- Katherine Bourzac
-
Outlook |
Q&A Eva Kahana: Ageing proactively
Why do some people cope better than others with getting old? Sociologist Eva Kahana, director of the Elderly Care Research Center at Case Western Reserve University, offers some clues.
- Rebecca Kessler
-
Outlook |
Centenarians: Great expectations
Scientists are searching for a genetic blueprint that will enable humans to stay healthy and vital well into their old age.
- Michael Eisenstein
-
News & Views |
Final act of senescence
Damaged cells can initiate cancer. To avert this, faulty cells disable their own propagation by undergoing senescence. But for full protection against liver cancer, the senescent cells must be cleared by the immune system. See Letter p.547
- Manuel Serrano
-
News & Views |
Old cells under attack
Age brings not just wisdom, but also, alas, many traits that to most of us are much less attractive. It now seems that, at least in mice, clearance of senescent cells delays some of the maladies associated with ageing. See Letter p.232
- Daniel S. Peeper
-
Letter |
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
- Tae-Won Kang
- , Tetyana Yevsa
- & Lars Zender
-
Letter |
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
- Darren J. Baker
- , Tobias Wijshake
- & Jan M. van Deursen
-
Research Highlights |
Senescence not so harmless
-
Letter |
CPEB and two poly(A) polymerases control miR-122 stability and p53 mRNA translation
- David M. Burns
- , Andrea D’Ambrogio
- & Joel D. Richter
-
Letter |
Opposing roles for calcineurin and ATF3 in squamous skin cancer
Calcineurin inhibitors are the mainstay of immunosuppressive treatment for organ transplant recipients. However, treatment with these drugs commonly leads to squamous cell carcinoma (SCC) of the skin. It is shown here that an intact calcineurin/NFAT signalling pathway is important for suppressing SCC development. Inhibition of this pathway leads to increased expression of the ATF3 protein, which has a key role in tumorigenesis.
- Xunwei Wu
- , Bach-Cuc Nguyen
- & G. Paolo Dotto
-
Article |
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence
Cellular senescence — an irreversible cell-cycle arrest — has been implicated in suppressing tumour formation or growth. A new cellular signalling pathway that drives senescence has now been identified. This pathway does not involve most known mediators of senescence, and instead signals via the proteins Atf4, p27 and p21. Inactivating the proto-oncogene Skp2 in the context of oncogenic signalling can induce senescence through this new pathway, indicating that drugs that target Skp2 might be useful in cancer treatment.
- Hui-Kuan Lin
- , Zhenbang Chen
- & Pier Paolo Pandolfi
-
News & Views |
A lower bar for senescence
Cellular senescence is a physiological mechanism for thwarting the proliferation of tumour cells. Encouraging cancer-prone cells to senesce might therefore be a way to nip this disease in the bud.
- Manuel Serrano