Featured
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Article
| Open Access
Fast and sensitive GCaMP calcium indicators for imaging neural populations
Using large-scale screening and structure-guided mutagenesis, fast and sensitive GCaMP sensors are developed and optimized with improved kinetics without compromising sensitivity or brightness.
- Yan Zhang
- , Márton Rózsa
- & Loren L. Looger
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Article
| Open Access
De novo design of luciferases using deep learning
A deep-learning-based strategy is used to design artificial luciferases that catalyse the oxidative chemiluminescence of diphenylterazine with high substrate specificity and catalytic efficiency.
- Andy Hsien-Wei Yeh
- , Christoffer Norn
- & David Baker
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Article |
A phosphoinositide signalling pathway mediates rapid lysosomal repair
Lysosomal membrane damage triggers a lipid signalling pathway that repairs lysosomes via lipid transport at newly established endoplasmic reticulum–lysosomal membrane contact sites.
- Jay Xiaojun Tan
- & Toren Finkel
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Article |
A tissue-like neurotransmitter sensor for the brain and gut
NeuroString, a tissue-like biological interface created by laser patterning of polyimide into a graphene/nanoparticle network embedded in an elastomer, is introduced, allowing in vivo real-time detection of neurotransmitters in the brain and gut.
- Jinxing Li
- , Yuxin Liu
- & Zhenan Bao
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Letter |
Dynamics of phosphoinositide conversion in clathrin-mediated endocytic traffic
‘Coincidence-detecting’ phosphoinositide sensors are used to study changes in the phosphoinositide lipid species found in membranes during the development and maturation of endocytic clathrin-coated vesicles.
- Kangmin He
- , Robert Marsland III
- & Tom Kirchhausen
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Brief Communications Arising |
The ‘mitoflash’ probe cpYFP does not respond to superoxide
- Markus Schwarzländer
- , Stephan Wagner
- & Michael P. Murphy
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Outlook |
Technology: Dressed to detect
Wearable devices that monitor seizures promise improvements in epilepsy treatments and research.
- Elie Dolgin
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Article |
Ultrasensitive fluorescent proteins for imaging neuronal activity
Sensitive protein sensors of calcium have been created; these new tools are shown to report neural activity in cultured neurons, flies and zebrafish and can detect single action potentials and synaptic activation in the mouse visual cortex in vivo.
- Tsai-Wen Chen
- , Trevor J. Wardill
- & Douglas S. Kim
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Letter |
A novel sensor to map auxin response and distribution at high spatio-temporal resolution
A new auxin sensor is used to reveal complex dynamic patterns of hormone distribution in development.
- Géraldine Brunoud
- , Darren M. Wells
- & Teva Vernoux
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News & Views |
Bacteria collaborate to sense arsenic
A method developed to allow rapid communication between bacterial cells across long distances enables the cells to detect arsenic collectively, and to report it as an oscillatory output. See Article p.39
- Christopher A. Voigt
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News |
Glowing cells guide cancer surgeons
Tumour-specific label pinpoints malignant cells.
- Zoe Cormier
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Research Highlights |
Bacteria 'blink' to expel molecules
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Article
| Open Access
An integrated semiconductor device enabling non-optical genome sequencing
- Jonathan M. Rothberg
- , Wolfgang Hinz
- & James Bustillo
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Research Highlights |
A microscopist's litmus test
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Research Highlights |
Fluorescent cells turned into lasers
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Research Highlights |
Probing for pancreatic cancer
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Research Highlights |
Slip and slide pores for sensors
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Research Highlights |
Chemistry: The hunt for explosives
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Research Highlights |
Biochemistry: Zooming in on proteins
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News & Views |
Dark-hot resonances
The resonant behaviour of clusters of gold nanoparticles has been tuned by gradually bringing the particles together. The approach could have many applications, including chemical and biological sensing.
- Mark I. Stockman
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Research Highlights |
Materials science: Skin-like sensors
Indefinite and bidirectional near-infrared nanocrystal photoswitching