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Letter |
Dilution of the cell cycle inhibitor Whi5 controls budding-yeast cell size
Saccharomyces cerevisiae controls its cell size through the differential size-dependency of the synthesis of the cell cycle activator Cln3 relative to the cell cycle inhibitor Whi5.
- Kurt M. Schmoller
- , J. J. Turner
- & Jan M. Skotheim
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Letter |
Cell-intrinsic adaptation of lipid composition to local crowding drives social behaviour
Little is known about how individual cells within a group of cells exposed to the same external signals can produce a specific individual response to their local microenvironment; a quantitative analysis of cell crowding reveals that single cells can autonomously sense local crowding though their ability to spread and activate focal adhesion kinase (FAK), which ultimately results in changes in cellular lipid composition.
- Mathieu Frechin
- , Thomas Stoeger
- & Lucas Pelkmans
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Letter |
Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle
A mathematical method, known as ergodic rate analysis, has been developed and used to study the rates of molecular events from single time measurements of large populations of fixed cells; this new method is able to overcome some of the previous limitations with regards to studying cell-size control.
- Ran Kafri
- , Jason Levy
- & Marc W. Kirschner
Chemotaxis as a navigation strategy to boost range expansion