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Skin cancer can involve melanocytes, leading to melanoma, but there are other non-melanoma skin cancers. These include basal cell carcinoma, squamous cell carcinoma and, less commonly, Merkel cell carcinoma, Kaposis sarcoma and T-cell lymphoma of the skin.
Xin et al. show, through intravital imaging, that KrasG12D induces epithelial tissue deformation in a spatiotemporally specific manner by converting the pulsatile ERK signal fluctuation in stem cells into sustained activation.
Leveraging the expertise of physicians to identify medically meaningful features in ‘counterfactual’ images produced via generative machine learning facilitates the auditing of the inference process of medical-image classifiers, as shown for dermatology images.
In this study, Bansaccal et al. analyse why, at some skin locations, oncogene-expressing cells rarely progress to cancer and found that a dense dermal collagen network prevents skin cancer formation.