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Kinase signalling in excitatory neurons regulates sleep quantity and depth
Forward genetics analyses and targeted genetic manipulation in mice show that regulation of sleep quantity and quality is mediated by the LKB1–SIK3–HDAC4–HDAC5 pathway.
- Staci J. Kim
- , Noriko Hotta-Hirashima
- & Hiromasa Funato
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Article |
Sensory processing during sleep in Drosophila melanogaster
The authors develop a paradigm to study sensory discrimination during sleep in Drosophila melanogaster.
- Alice S. French
- , Quentin Geissmann
- & Giorgio F. Gilestro
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Article |
Chronic social isolation signals starvation and reduces sleep in Drosophila
Behavioural and transcriptomic analyses show that chronic social isolation of Drosophila causes perturbed sleep and increased feeding, and induces a starvation-like brain state.
- Wanhe Li
- , Zikun Wang
- & Michael W. Young
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Article |
Neural signatures of sleep in zebrafish
Fluorescence-based polysomnography in zebrafish reveals two major sleep signatures that share features with those of amniotes, which suggests that common neural sleep signatures emerged in the vertebrate brain over 450 million years ago.
- Louis C. Leung
- , Gordon X. Wang
- & Philippe Mourrain
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Letter |
A potassium channel β-subunit couples mitochondrial electron transport to sleep
Sleep deprivation in Drosophila elevates reactive oxygen species in sleep-promoting neurons, leading to changes in potassium currents and spiking activity and thereby connecting energy metabolism, oxidative stress, and sleep.
- Anissa Kempf
- , Seoho M. Song
- & Gero Miesenböck
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Letter |
Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep
GABAergic Lhx6+ neurons in the ventral zona incerta promote both rapid eye movement and non-rapid eye movement sleep and inhibit the activity of wake-promoting GABAergic and Hcrt+ neurons of the lateral hypothalamus.
- Kai Liu
- , Juhyun Kim
- & Seth Blackshaw
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Letter |
Identification of preoptic sleep neurons using retrograde labelling and gene profiling
Identification of sleep-active and sleep-promoting neurons in the preoptic area of the hypothalamus using neural projection tracing tools to target this population among a group of intermingled neurons, all with various functions.
- Shinjae Chung
- , Franz Weber
- & Yang Dan
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Article |
Forward-genetics analysis of sleep in randomly mutagenized mice
Two mutations affecting the sleep–wakefulness balance in mice are detected, showing that the SIK3 protein kinase is essential for determining daily wake time, and the NALCN cation channel regulates the duration of rapid eye movement sleep.
- Hiromasa Funato
- , Chika Miyoshi
- & Masashi Yanagisawa
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Article |
Circadian neuron feedback controls the Drosophila sleep–activity profile
A subset of dorsal clock neurons are identified in Drosophila as sleep-promoting cells, which participate in a feedback loop with pacemaker neurons to drive both midday siesta and night-time sleep.
- Fang Guo
- , Junwei Yu
- & Michael Rosbash
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Outlook |
Neuroscience: Off to night school
One of sleep's most important functions is processing memory. Researchers are now starting to figure out how the brain helps us learn when we're asleep.
- Kerri Smith
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Outlook |
Neurodegeneration: Amyloid awakenings
Sleep disturbances may be an early sign of neurodegenerative diseases — but could sleep deficits cause these conditions in the first place?
- Moheb Costandi
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Outlook |
Deprivation: A wake-up call
Studies that restrict sleep show why a lack of shut-eye can lead to serious chronic disease.
- Elie Dolgin
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Outlook |
Perspective: Casting light on sleep deficiency
The use of electric lights at night is disrupting the sleep of more and more people, says Charles Czeisler.
- Charles A. Czeisler
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Outlook |
Mood disorders: The dark night
The causal relationships between lack of sleep and mood disorders remain murky. But one thing is clear as day: better sleep can have psychological benefits.
- Sarah DeWeerdt
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Outlook |
Obesity: Heavy sleepers
A growing body of evidence shows that getting a good night's sleep plays an important role in regulating the body's metabolism.
- Brian Owens
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Outlook |
Insomnia: Chasing the dream
A combination of drugs and cognitive behavioural therapy may finally put an end to the misery of sleepless nights.
- James Mitchell Crow
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Outlook |
Chronobiology: Stepping out of time
How can people better adapt to an 'unnatural' world of artificial lighting and alarm clocks?
- Michael Eisenstein
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News |
Scientists read dreams
Brain scans during sleep can decode visual content of dreams.
- Mo Costandi
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News |
Disrupted sleep may predict Alzheimer’s
Poor sleep patterns linked to formation of Alzheimer's plaques.
- Mo Costandi
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Research Highlights |
Memory boost with sleep
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News |
How to learn in your sleep
New information can be learned while asleep, and retained after waking.
- Mo Costandi
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News & Views |
Sleepy neurons?
A study in rats suggests that individual neurons take a nap when the brain is forced to stay awake, and that the basic unit of sleep is the electrical activity of single cortical neurons. See Article p.443
- Christopher S. Colwell
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News |
Surreptitious sleep states uncovered
Sleep-deprived rats suggest sleep is not necessarily a whole-brain phenomenon.
- Virginia Gewin
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Research Highlights |
Sleep strengthens memories
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Letter |
Preplay of future place cell sequences by hippocampal cellular assemblies
Place cells in the hippocampus track an animal's position as it travels through space. Previous work contends that sequential place cell maps are produced upon the initial navigation of a new area and subsequently consolidated at rest or during sleep. Here, place-cell firing patterns during rest or sleep are observed before a novel spatial experience, a phenomenon termed 'preplay'. These sequences were separate from the replay of pervious experience and suggest that internal dynamics during rest may organize cell assemblies to be ready for any novel encoding that may occur in the immediate future.
- George Dragoi
- & Susumu Tonegawa
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News Feature |
Science communication: Scientist as star
Sleep researcher Sara Mednick has straddled the line between media darling and respected scientist. But why is there still a line at all?
- Erik Vance
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News |
A wake-up call for dozing Drosophila
Association study shows that the genetics of sleep are as complex in flies as in humans.
- Virginia Hughes