Somatic hypermutation articles within Nature

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• Article
  26 October 2022 | Open Access

  Functional antibodies exhibit light chain coherence

   Among naturally occurring antibodies that have adapted to antigen, those with similar heavy chains usually have similar light chains.

  • David B. Jaffe
  • , Payam Shahi
  •  & Wyatt J. McDonnell

• Article | 15 February 2022

  Germinal centre-driven maturation of B cell response to mRNA vaccination

  Sequencing of B cell receptors and expression of the corresponding monoclonal antibodies is used to characterize the evolution of the long-term B cell response to SARS-CoV-2 mRNA vaccination.

  • Wooseob Kim
  • , Julian Q. Zhou
  •  & Ali H. Ellebedy

• Article | 24 November 2021

  Fam72a enforces error-prone DNA repair during antibody diversification

  FAM72A interacts with UNG2 to regulate the balance between error-prone and error-free DNA repair.

  • Mélanie Rogier
  • , Jacques Moritz
  •  & Bernardo Reina-San-Martin

• Letter | 25 September 2019

  Analysis of the B cell receptor repertoire in six immune-mediated diseases

  An analysis of the B cell receptor repertoire in six immune-mediated diseases reveals that there are substantial differences in clonality, isotype use, class switching and use of the IGHV genes between diseases.

  • R. J. M. Bashford-Rogers
  • , L. Bergamaschi
  •  & K. G. C. Smith

• Letter | 05 October 2014

  Rapid development of broadly influenza neutralizing antibodies through redundant mutations

  The main pathway of somatic mutations leading to the generation of high affinity broadly neutralizing antibodies against the influenza haemagglutinin stem is defined.

  • Leontios Pappas
  • , Mathilde Foglierini
  •  & Antonio Lanzavecchia