Article
|
Open Access
Featured
-
-
Article |
A male germ-cell-specific ribosome controls male fertility
RibosomeST—a ribosome with a specialized nascent polypeptide exit tunnel—cotranslationally regulates the folding of a subset of male germ-cell-specific proteins that are essential for the formation of sperm.
- Huiling Li
- , Yangao Huo
- & Jiahao Sha
-
Article
| Open Access
Histone H2B.8 compacts flowering plant sperm through chromatin phase separation
H2B.8 is identified as a histone variant that mediates a newly described mechanism of transcription-compatible chromatin condensation in flowering plant sperm cells.
- Toby Buttress
- , Shengbo He
- & Xiaoqi Feng
-
Article |
SPOCD1 is an essential executor of piRNA-directed de novo DNA methylation
Newly identified protein SPOCD1 is crucial in de novo DNA methylation directed by PIWI proteins and piRNAs, helping to control DNA silencing in mouse male germline.
- Ansgar Zoch
- , Tania Auchynnikava
- & Dónal O’Carroll
-
Research Highlights |
Molecule blocks sperm production
-
Letter |
The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements
- Serena De Fazio
- , Nenad Bartonicek
- & Dónal O’Carroll
-
News & Views |
In vitro sperm maturation
Anticancer therapies can impair male fertility. Whereas men can opt to freeze their sperm before treatment, young boys don't produce mature sperm and so lack this choice. Work in mice offers hope for such patients. See Letter p.504
- Marco Seandel
- & Shahin Rafii
-
Letter |
In vitro production of functional sperm in cultured neonatal mouse testes
Reproducing the complex process of spermatogenesis in vitro might lead to the development of new diagnostic and therapeutic techniques for male infertility. This study establishes in vitro organ culture conditions that can support complete spermatogenesis in mice. The in-vitro-derived spermatids and sperm produced healthy and fertile mice, and testis tissue fragments used as a starting material for in vitro spermatogenesis could be cryopreserved for months and then resumed full spermatogenesis in vitro.
- Takuya Sato
- , Kumiko Katagiri
- & Takehiko Ogawa
-
Research Highlights |
Molecular evolution: Sperm-making origins
Inheritance of paternal DNA damage by histone-mediated repair restriction