Squamous cell carcinoma articles within Nature

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  • Article
    | Open Access

    Aberrant crosstalk between cancer stem cells and their microenvironment triggers angiogenesis and TGFβ signalling, creating conditions that are conducive for hijacking leptin and leptin receptor signalling, which in turn launches downstream PI3K–AKT–mTOR signalling during the benign-to-malignant transition.

    • Shaopeng Yuan
    • , Katherine S. Stewart
    •  & Elaine Fuchs

  • Article |

    A mouse model of papillomavirus infection reveals that skin colonization with commensal papillomaviruses protects the immunocompetent host against chemical- and UV-induced skin cancer through CD8+ T cell immunity.

    • John D. Strickley
    • , Jonathan L. Messerschmidt
    •  & Shadmehr Demehri

  • Article |

    A new approach is used to target BET family bromodomains which are found in transcriptional regulators where they mediate the recognition of acetyl-lysine chromatin marks. Structural data reveal how the compound JQ1 binds to the bromodomain of BRD4. BRD4 has been implicated in a subtype of human squamous carcinomas, and JQ1 is found to inhibit the growth of BRD4 dependent tumours in mouse models.

    • Panagis Filippakopoulos
    • , Jun Qi
    •  & James E. Bradner

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