Stalled forks articles within Nature

Featured

• Article | 04 March 2020

  Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms

  DNA interstrand crosslinks induced by acetaldehyde are repaired by both the Fanconi anaemia pathway and by a second, excision-independent repair mechanism.

  • Michael R. Hodskinson
  • , Alice Bolner
  •  & Puck Knipscheer

• Article | 03 July 2019

  Isomerization of BRCA1–BARD1 promotes replication fork protection

  BRCA1–BARD1 has a role in replication fork protection that is mediated by a mechanism of phosphorylation-targeted isomerization of BRCA1 and is independent of the canonical interaction between BRCA1 and PALB2.

  • Manuel Daza-Martin
  • , Katarzyna Starowicz
  •  & Joanna R. Morris

• Letter | 27 June 2018

  High speed of fork progression induces DNA replication stress and genomic instability

  Inhibition of PARP is shown to accelerate the speed of replication fork elongation, which prevents fork stalling and induces DNA damage, with implications for genomic instability and cancer treatment.

  • Apolinar Maya-Mendoza
  • , Pavel Moudry
  •  & Jiri Bartek

• Article | 18 April 2018

  SAMHD1 acts at stalled replication forks to prevent interferon induction

  SAMHD1 has an essential role in the replication stress response and prevents inflammation by activating the MRE11 nuclease to degrade nascent DNA strands at stalled replication forks, thus enabling replication.

  • Flavie Coquel
  • , Maria-Joao Silva
  •  & Philippe Pasero

• Article | 20 July 2016

  Replication fork stability confers chemoresistance in BRCA-deficient cells

  Protection of nascent DNA from degradation provides a mechanism that can promote synthetic viability and drug resistance in Brca-deficient cells without restoring homologous recombination at double-strand breaks.

  • Arnab Ray Chaudhuri
  • , Elsa Callen
  •  & André Nussenzweig

• Letter | 28 April 2014

  BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks

  Direct evidence for the role of BRCA1 in controlling homologous recombination at stalled replication forks has been obtained in mammalian cells using the bacterial Tus/Ter system.

  • Nicholas A. Willis
  • , Gurushankar Chandramouly
  •  & Ralph Scully

• Letter | 25 November 2012

  Recombination-restarted replication makes inverted chromosome fusions at inverted repeats

  A new mechanism of chromosomal rearrangement is identified through the observation that broken or collapsed DNA replication forks restarted by homologous recombination have a high propensity for U-turns at short inverted repeats; the error-prone nature of this mechanism is suggested to contribute to gross chromosomal rearrangements and copy-number variations present in cancer and other genomic disorders.

  • Ken’Ichi Mizuno
  • , Izumi Miyabe
  •  & Johanne M. Murray