Steroid hormones articles within Nature

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  • Article |

    Comparisons of steroid hormone concentrations in dentin samples from fossil mammoth tusks with those from a modern elephant tusk provide evidence of periodic increases in testosterone in the male mammoth characteristic of musth episodes.

    • Michael D. Cherney
    • , Daniel C. Fisher
    •  & Alexei N. Tikhonov

  • Article |

    The cryo-electron microscopy structure of the glucocorticoid receptor (GR)-loading complex—a complex in which Hsp70 loads GR onto Hsp90 and Hop—is described, providing insights into how the chaperones Hsp90 and Hsp70 coordinate to facilitate GR remodelling for activation.

    • Ray Yu-Ruei Wang
    • , Chari M. Noddings
    •  & David A. Agard

  • Letter |

    Reproductive history influences breast cancer risk but the cellular mechanisms are unclear. Here it is shown that ovarian hormones regulate the size of the mammary stem cell pool in mice. The size of this pool increases when progesterone levels increase during the reproductive cycle. Progesterone probably regulates stem cell numbers through a paracrine mechanism involving induction of RANKL and Wnt in luminal cells.

    • Purna A. Joshi
    • , Hartland W. Jackson
    •  & Rama Khokha

  • News & Views |

    The steroid hormones oestrogen and progesterone have a role in sickness and in health. In breast tissue, both roles probably work through a single mechanism: controlling the number and activity of mammary stem cells.

    • John P. Lydon

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