Stress and resilience

Article | 08 May 2024

Structural pharmacology and therapeutic potential of 5-methoxytryptamines

Detailed analyses of the serotonin receptor 5-HT_1A and the psychedelic 5-methoxy-N,N-dimethyltryptamine reveal the differences in receptor structural pharmacology that mediate signalling specificity, efficacy and potency, findings that may facilitate the development of new neuropsychiatric therapeutics.

Audrey L. Warren
, David Lankri
& Daniel Wacker

Article
30 November 2022 | Open Access

Social trauma engages lateral septum circuitry to occlude social reward

The authors show that, in a chronic social defeat stress rodent model, a subset of male and female mice avoided social interaction with non-aggressive, same-sex juvenile mice and did not develop context-dependent social reward following these encounters.

Long Li
, Romain Durand-de Cuttoli
& Scott J. Russo

Article | 19 October 2022

Behavioural and dopaminergic signatures of resilience

Neural recording and closed-loop manipulation during chronic stress in mice reveal causal links between dopamine, behavior and resilience.

Lindsay Willmore
, Courtney Cameron
& Annegret L. Falkner

Letter | 27 June 2018

Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus

Adult neurogenesis in the hippocampus confers resilience to chronic stress in mice by inhibiting the activity of mature granule cells in the ventral dentate gyrus.

Christoph Anacker
, Victor M. Luna
& René Hen

Letter | 27 September 2017

Retrograde semaphorin–plexin signalling drives homeostatic synaptic plasticity

At the neuromuscular junction in Drosophila, signalling from postsynaptic Sema2b to presynaptic PlexB controls presynaptic homeostatic plasticity through Mical-mediated regulation of the readily releasable pool of synaptic vesicles.

Brian O. Orr
, Richard D. Fetter
& Graeme W. Davis

Letter | 17 June 2015

Activating positive memory engrams suppresses depression-like behaviour

Acute re-activation of a positive memory engram suppresses depression-like behaviour in mice exposed to chronic stress, mediated by a hippocampus–amygdala–nucleus-accumbens pathway.

Steve Ramirez
, Xu Liu
& Susumu Tonegawa

Outlook | 19 December 2012

Psychodermatology: An emotional response

As the link between stress and psoriasis flare-ups becomes clearer, it seems the most vulnerable patients require a new type of treatment.

Sarah DeWeerdt

Outlook | 19 December 2012

Q&A: Under their skin

Psoriasis can have a profound impact on patients' emotional and social lives. Christopher Griffiths, a dermatologist at the University of Manchester in the United Kingdom, discusses the disease's psychological fallout and its links with stress.