Striate cortex articles within Nature

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  • Article
    | Open Access

    Two-photon imaging and in situ transcriptomic analysis of the primary visual cortex in mice show that a single transcriptomic axis correlates with the state modulation of cortical inhibitory neurons.

    • Stéphane Bugeon
    • , Joshua Duffield
    •  & Kenneth D. Harris

  • Article |

    The mouse neocortex supports sensory performance through transient increases in sensory coding redundancy, neural codes that are robust to cellular variability, and inter-area fluctuation modes that transmit sensory data and task responses in non-interfering channels.

    • Sadegh Ebrahimi
    • , Jérôme Lecoq
    •  & Mark J. Schnitzer

  • Article |

    Live neuron imaging and electron microscopy reconstruction shows that the selectivity of cortical neuron responses to visual stimuli arises from the total number of synapses activated rather than being dominated by a small number of strong synaptic inputs.

    • Benjamin Scholl
    • , Connon I. Thomas
    •  & David Fitzpatrick

  • Article |

    A microscopy system that enables simultaneous recording from hundreds of neurons in the mouse visual cortex reveals that the brain enhances its coding capacity by representing visual inputs in dimensions perpendicular to correlated noise.

    • Oleg I. Rumyantsev
    • , Jérôme A. Lecoq
    •  & Mark J. Schnitzer

  • Letter |

    Mapping the organization of excitatory inputs onto the dendritic spines of individual mouse visual cortex neurons reveals how inputs representing features from the extended visual scene are organized and establishes a computational unit suited to amplify contours and elongated edges.

    • M. Florencia Iacaruso
    • , Ioana T. Gasler
    •  & Sonja B. Hofer

  • Article |

    Recordings from cat visual cortex show that the cortical maps for stimulus orientation, direction and retinal disparity depend on an organization in which thalamic axons with similar retinotopy and light/dark responses are clustered together in the cortex.

    • Jens Kremkow
    • , Jianzhong Jin
    •  & Jose M. Alonso

  • Letter |

    Two-photon calcium imaging and electron microscopy were used to explore the relationship between structure and function in mouse primary visual cortex, showing that layer 2/3 neurons are connected in subnetworks, that pyramidal neurons with similar orientation selectivity preferentially form synapses with each other, and that neurons with similar orientation tuning form larger synapses; this study exemplifies functional connectomics as a powerful method for studying the organizational logic of cortical networks.

    • Wei-Chung Allen Lee
    • , Vincent Bonin
    •  & R. Clay Reid

  • Letter |

    Exploring the relationship between population coupling and neuronal activity reveals that neighbouring neurons can differ in their coupling to the overall firing rate of the population, the circuitry of which may potentially help to explain the complex activity patterns in cortical populations.

    • Michael Okun
    • , Nicholas A. Steinmetz
    •  & Kenneth D. Harris

  • Letter |

    In complex networks of the cerebral cortex, the majority of connections are weak and only a minority strong, but it is not known why; here the authors show that excitatory neurons in primary visual cortex follow a rule by which strong connections are sparse and occur between neurons with correlated responses to visual stimuli, whereas only weak connections link neurons with uncorrelated responses.

    • Lee Cossell
    • , Maria Florencia Iacaruso
    •  & Thomas D. Mrsic-Flogel

  • Letter |

    A study of mouse visual cortex relating patterns of excitatory synaptic connectivity to visual response properties of neighbouring neurons shows that, after eye opening, local connectivity reorganizes extensively: more connections form selectively between neurons with similar visual responses and connections are eliminated between visually unresponsive neurons, but the overall connectivity rate does not change.

    • Ho Ko
    • , Lee Cossell
    •  & Thomas D. Mrsic-Flogel

  • Letter |

    Visual responses during wakefulness are dominated by inhibition, and this inhibition shapes visual selectivity by restricting the temporal and spatial extent of neural activity.

    • Bilal Haider
    • , Michael Häusser
    •  & Matteo Carandini

  • Article |

    To date, various aspects of connectivity have been inferred from electron microscopy (EM) of synaptic contacts, light microscopy of axonal and dendritic arbors, and correlations in activity. However, until now it has not been possible to relate the complex structural wiring between neurons to the function of individual cells. Using a combination of functional imaging and three-dimensional serial EM reconstruction at unprecedented scale, two papers now describe the connectivity of single cells in the mouse visual system. This study investigates the connectivity of inhibitory interneurons in primary visual cortex.

    • Davi D. Bock
    • , Wei-Chung Allen Lee
    •  & R. Clay Reid

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