Sumoylated proteins articles within Nature

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  • Letter |

    Activation of inflammatory gene expression by toll-like receptor (TLR) signalling pathways involves the removal of gene repression complexes such as NCoR. Here, coronin 2A, a component of the NCoR complex, is shown to mediate TLR-induced NCoR turnover and de-repression of inflammatory genes by a mechanism involving interaction with oligomeric nuclear actin.

    • Wendy Huang
    • , Serena Ghisletti
    •  & Christopher K. Glass

  • Article |

    The post-translational modification of cellular proteins by ubiquitin (Ub) and ubiquitin-like (Ubl) proteins — such as SUMO — regulates a broad array of cellular processes. E1 enzymes activate Ub and Ubl in two steps, by carboxy-terminal adenylation and thioester bond formation to a catalytic cysteine, but the structural basis for the intermediates remains unknown. Crystal structures for SUMO E1 in complex with SUMO adenylate and tetrahedral intermediate analogues are now reported and analysed.

    • Shaun K. Olsen
    • , Allan D. Capili
    •  & Christopher D. Lima

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