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Ultrafast endocytosis at mouse hippocampal synapses
Sustained neurotransmission requires recycling of synaptic vesicles, but the proposed mechanisms have been controversial; here a ‘flash-and-freeze’ method for electron microscopy reveals a new ultrafast form of endocytosis that is actin- and dynamin-dependent and occurs within 100 milliseconds of stimulation.
- Shigeki Watanabe
- , Benjamin R. Rost
- & Erik M. Jorgensen