TOR signalling articles within Nature

Featured

  • Article
    | Open Access

    The cryo-EM structure of the yeast SEA complex suggests that SEACAT functions as a scaffold for binding TORC1 regulators.

    • Lucas Tafur
    • , Kerstin Hinterndorfer
    •  & Robbie Loewith

  • Article |

    The 3D structure of the human nutrient-sensing complex GATOR2 is resolved using cryo-electron microscopy.

    • Max L. Valenstein
    • , Kacper B. Rogala
    •  & David M. Sabatini

  • Article |

    A set of 34 excised introns in Saccharomyces cerevisiae, characterized by having a short distance between the lariat branch point and the 3′ splice site, have a biological function within the TOR growth-signalling network.

    • Jeffrey T. Morgan
    • , Gerald R. Fink
    •  & David P. Bartel

  • Article |

    The cryo-electron microscopy and crystal structures of several mTORC1 complexes, and accompanying biochemical analyses, shed light on how mTORC1 is regulated and how cancer mutations lead to its hyperactivation.

    • Haijuan Yang
    • , Xiaolu Jiang
    •  & Nikola P. Pavletich

  • Letter |

    Structural data on the protein CASTOR1 reveal how the mTORC1 pathway senses intracellular arginine, suggesting a repurposing of an evolutionarily pre-metazoan mechanism.

    • Robert A. Saxton
    • , Lynne Chantranupong
    •  & David M. Sabatini

  • Letter |

    The mTORC1 protein kinase complex integrates nutrient and growth stimuli to modulate signalling pathways that regulate cellular metabolism and physiology, but the molecular nature of the amino acid sensing mechanism at the lysosome is unknown; here, an orphan member of the human solute carrier group of proteins, SLC38A9, is shown to be an integral component of the lysosomal machinery that can directly sense amino acids and activate mTORC1.

    • Manuele Rebsamen
    • , Lorena Pochini
    •  & Giulio Superti-Furga

  • Article |

    The translation of many messenger RNAs that encode important oncogenes and transcription factors depends on the eIF4A RNA helicase to resolve G-quadruplex structures, implying eIF4A inhibition as an effective cancer therapy.

    • Andrew L. Wolfe
    • , Kamini Singh
    •  & Hans-Guido Wendel

  • Article |

    Co-crystal structures of a number of complexes involving truncated mammalian target of rapamycin, a phosphoinositide 3-kinase-related protein kinase, reveal an intrinsically active kinase conformation and show how rapamycin–FKBP12 directly blocks substrate recruitment to the kinase domain.

    • Haijuan Yang
    • , Derek G. Rudge
    •  & Nikola P. Pavletich

  • News & Views |

    Understanding how a low calorie intake slows ageing could revolutionize the way that we treat age-related diseases. One potential key to such treatments could be to enhance the local environment of stem cells. See Article p.490

    • Fresnida J. Ramos
    •  & Matt Kaeberlein

  • News & Views |

    A genome-wide characterization of active translation of messenger RNA following inhibition of mTOR will transform our view of this signalling protein's regulatory role in cancer. See Article p.55 & Letter p.109

    • Antonio Gentilella
    •  & George Thomas

  • Letter |

    During periods of fasting the liver produces ketone bodies, which the peripheral tissues can use as a source of energy. Here it is shown that fasting inhibits multi-component mTOR complex 1 (mTORC1) in the liver. Inhibition of mTORC1 is required for activation of PPARα, a master regulator that switches on genes involved in ketogenesis. Livers from aged mice have increased mTORC1 signalling, reduced PPARα activity, and reduced ketone production. The observation that mTORC1 promotes an ageing phenotype in the liver fits well with the observation that inhibition of this pathway increases lifespan in several organisms.

    • Shomit Sengupta
    • , Timothy R. Peterson
    •  & David M. Sabatini

  • Letter |

    When cells are starved, the enzyme TOR is inhibited, inducing autophagy. In this process, autophagosomes sequester intracellular components and then fuse with lysosomes, producing autolysosomes in which cargo is degraded to regenerate nutrients. Now, a mechanism is revealed by which lysosomes are re-formed. When starvation conditions are prolonged, mTOR is re-activated; this attenuates autophagy and results in tubules and vesicles extruding from the autolysosome and maturing into functional lysosomes.

    • Li Yu
    • , Christina K. McPhee
    •  & Michael J. Lenardo

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