Totipotent stem cells articles within Nature

Featured

• Article | 21 June 2022

  Induction of mouse totipotent stem cells by a defined chemical cocktail

  Under chemically defined conditions, mouse pluripotent stem cells can be induced to closely resemble authentic totipotent stem cells that can differentiate to both embryonic and extraembryonic lineages.

  • Yanyan Hu
  • , Yuanyuan Yang
  •  & Sheng Ding

• Article | 21 March 2022

  Rolling back human pluripotent stem cells to an eight-cell embryo-like stage

  The development of a transgene-free, rapid and controllable method for producing eight-cell-like cells from human pluripotent stem cells provides a valuable resource to study early human embryogenesis.

  • Md. Abdul Mazid
  • , Carl Ward
  •  & Miguel A. Esteban

• Letter | 11 October 2017

  Establishment of mouse expanded potential stem cells

  Cultures of expanded potential stem cells can be established from individual eight-cell blastomeres, and by direct conversion of mouse embryonic stem cells and induced pluripotent stem cells, highlighting the feasibility of establishing expanded potential stem cells for other mammalian species.

  • Jian Yang
  • , David J. Ryan
  •  & Pentao Liu

• Brief Communications Arising | 24 September 2015

  Failure to replicate the STAP cell phenomenon

  • Alejandro De Los Angeles
  • , Francesco Ferrari
  •  & George Q. Daley

• Review Article | 23 September 2015

  Hallmarks of pluripotency

  In response to the need for a defined set of criteria to assess stem-cell potency, this review proposes guidelines for the evaluation of newly derived pluripotent stem cells, from functional assays to integrative molecular analyses of transcriptional, epigenetic and metabolic states.

  • Alejandro De Los Angeles
  • , Francesco Ferrari
  •  & George Q. Daley