Featured
-
-
Letter |
A tethering complex drives the terminal stage of SNARE-dependent membrane fusion
Tethering proteins, known to mediate initial recognition and attachment during membrane fusion, are essential for driving the transition from the hemifused state to fusion pore formation.
- Massimo D’Agostino
- , Herre Jelger Risselada
- & Andreas Mayer
-
Article |
Postsynaptic synaptotagmins mediate AMPA receptor exocytosis during LTP
Postsynaptic synaptotagmin-1 and synaptotagmin-7 mediate calcium-dependent exocytosis of AMPA receptors during long-term potentiation.
- Dick Wu
- , Taulant Bacaj
- & Thomas C. Südhof
-
Article |
Clathrin regenerates synaptic vesicles from endosomes
Ultrastructural analysis of synaptic vesicle recycling reveals that clathrin is not required for the initial rapid step of vesicle recycling by ultrafast endocytosis at the plasma membrane and instead clathrin acts later at an endosome to regenerate synaptic vesicles; however, when ultrafast endocytosis does not occur (for example, in experiments at room temperature rather than physiological temperature), clathrin-mediated endocytosis does happen at the plasma membrane.
- Shigeki Watanabe
- , Thorsten Trimbuch
- & Erik M. Jorgensen
-
News & Views |
Conservation in vesicle coats
Coat proteins of vesicles involved in intracellular membrane trafficking have closely related molecular architectures. The structure of COPI extends known similarities, and strengthens the case for a common evolutionary origin.
- Stephen C. Harrison
- & Tomas Kirchhausen
Fast resupply of synaptic vesicles requires synaptotagmin-3