Featured
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Article |
SARS-CoV-2 Omicron variant replication in human bronchus and lung ex vivo
Omicron replicates faster than the wild-type, D614G, Alpha, Beta and Delta SARS-CoV-2 variants in the bronchi but less efficiently in the lung parenchyma.
- Kenrie P. Y. Hui
- , John C. W. Ho
- & Michael C. W. Chan
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Article |
Spike mutation D614G alters SARS-CoV-2 fitness
The SARS-CoV-2 variant expressing spike(D641G) shows increased infectivity in human lung epithelial cells and in hamster and primary human upper airway tissues, but is more susceptible to neutralization by antibodies raised against SARS-CoV-2.
- Jessica A. Plante
- , Yang Liu
- & Pei-Yong Shi
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Article |
Pathogenesis and transmission of SARS-CoV-2 in golden hamsters
The pathogenicity and transmissibility of SARS-CoV-2 in golden (Syrian) hamsters resemble features of COVID-19 in human patients, suggesting that these hamsters could be used to model this disease.
- Sin Fun Sia
- , Li-Meng Yan
- & Hui-Ling Yen
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Letter |
Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes
A mutation that increases the secretion of Zika virus non-structural protein 1 (NS1) in infected hosts enhances the ability of the virus to infect its mosquito vector Aedes aegypti and might have contributed to the recent Zika epidemic.
- Yang Liu
- , Jianying Liu
- & Gong Cheng
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Letter |
Pathogenesis and transmission of avian influenza A (H7N9) virus in ferrets and mice
The new H7N9 influenza virus, recently emerged in China, can replicate in human airway cells and in the respiratory tract of ferrets to a higher level than can seasonal H3N2 virus and shows higher lethality in mice than genetically related H7N9 and H9N2 viruses, but shows limited transmission in ferrets by respiratory droplets.
- Jessica A. Belser
- , Kortney M. Gustin
- & Terrence M. Tumpey
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News |
Breast-milk molecule raises risk of HIV transmission
Although one type of sugar in breast milk from HIV-positive mothers can boost likelihood of transmission, many other sugars protect against disease.
- Anna Petherick
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News |
Europe on alert for flying invaders
Spread of disease-carrying mosquitoes prompts guidelines for boosting surveillance.
- Declan Butler
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News |
Pig fever sweeps across Russia
Deadly virus may be poised to spread to neighbouring states.
- Ewen Callaway
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Letter |
HIV-infected T cells are migratory vehicles for viral dissemination
Using intravital microscopy, this study visualizes HIV-1-infected T cells within the lymph nodes of humanized mice, demonstrating that infected cells have reduced motility and long membrane processes; treating infected mice with a lymphocyte egress inhibitor prevents HIV-1 from spreading to the circulation during the course of treatment.
- Thomas T. Murooka
- , Maud Deruaz
- & Thorsten R. Mempel
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News |
Freeze on mutant-flu research set to thaw
But some fear that if more labs work on the viruses, the risk of accidental release will multiply.
- Declan Butler
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World View |
Do not censor science in the name of biosecurity
Security officials should not be concerned about the publication of mutant-flu research, says bio-weapons expert Tim Trevan.
- Tim Trevan
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News Feature |
Bird-flu research: The biosecurity oversight
The fight over mutant flu has thrown the spotlight on a little-known government body that oversees dual-use research. Some are asking if it was up to the task.
- Brendan Maher
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News & Views |
Bird flu in mammals
An engineered influenza virus based on a haemagglutinin protein from H5N1 avian influenza, with just four mutations, can be transmitted between ferrets, emphasizing the potential for a human pandemic to emerge from birds. See Letter p.420
- Hui-Ling Yen
- & Joseph Sriyal Malik Peiris
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Letter
| Open Access
Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets
Only four mutations in H5N1 HA are required to enable ferret-to-ferret transmission of a reassortant virus containing the H5 HA and the remaining seven gene segments from a human pandemic H1N1 influenza virus.
- Masaki Imai
- , Tokiko Watanabe
- & Yoshihiro Kawaoka
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News |
Flu surveillance lacking
Nature analysis highlights need for international strategy to watch for pandemic threats.
- Declan Butler
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News |
Flu meeting opts for openness
Controversial virus studies should be published and oversight of such work strengthened, conference concludes.
- Declan Butler
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Comment |
Q&A: Reasons for proposed redaction of flu paper
US National Science Advisory Board for Biosecurity explains recommendation to publish H5N1 work in a form that withholds essential data.
- Paul S. Keim
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Correspondence |
Pause on avian flu transmission studies
- Ron A. M. Fouchier
- , Adolfo García-Sastre
- & Yoshihiro Kawaoka
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Comment |
The fight over flu
A proposal to restrict the planned publication of research on a potentially deadly avian influenza virus is causing a furore. Ten experts suggest ways to proceed.
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News |
Modified mosquitoes set to quash dengue fever
Wolbachia infection expected to halt virus transmission in Australian trial.
- David Cyranoski
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News |
Call to censor flu studies draws fire
Critics say controversy over publication of mutant-H5N1 research highlights biosecurity weaknesses.
- Heidi Ledford
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News |
Respiratory virus jumps from monkeys to humans
Adenovirus remained infectious after crossing species barrier.
- Zoe Cormier
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Letter |
Long-term evolution and transmission dynamics of swine influenza A virus
- Dhanasekaran Vijaykrishna
- , Gavin J. D. Smith
- & J. S. Malik Peiris
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News |
Drugs to treat HIV found to prevent infection
Antiretroviral drugs shown to cut HIV transmission to men at high risk.
- Alla Katsnelson
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News |
Untangling HIV transmission in men
Study could put scientists on the right path to blocking the spread of new infections.
- Erika Check Hayden
Enteric viruses replicate in salivary glands and infect through saliva
Targeting early infection to prevent HIV-1 mucosal transmission