Abstract
Purpose
To evaluate the effect of mild posterior capsule opacity (PCO) on visual acuity (VA) in eyes implanted with a diffractive multifocal intraocular lens (IOL) compared with a monofocal IOL, and the effect of posterior continuous curvilinear capsulorhexis (PCCC) combined with diffractive multifocal IOL implantation.
Methods
For the initial evaluation, we compared charge-coupled device (CCD) camera photographs taken through both a monofocal IOL-loaded model eye and a diffractive IOL-loaded model eye under the conditions of both with and without an opaque filter for the simulation of mild PCO. The clinical evaluation involved 20 patients who underwent bilateral implantation of the same diffractive multifocal IOL. In all 20 cases, PCCC was performed in 1 eye (PCCC group) and not performed in the fellow eye (NCCC group). Postoperative clinical results were then compared between the two groups.
Results
The CCD photographs revealed that the diffractive IOL-loaded eye was more strongly affected by the simulated PCO than was the monofocal IOL-loaded eye. In the clinical setting, the PCCC group registered better results than NCCC group in distance and near VA, low-contrast VA, and contrast sensitivity testing.
Conclusions
Diffractive multifocal IOLs tend to be more influenced by mild PCO than do monofocal IOLs, and PCCC prior to IOL implantation can contribute to the avoidance of this effect.
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Introduction
Since 2006, it has been reported that when using a diffractive multifocal intraocular lens (diffractive IOL), ‘hazy vision’ or ‘waxy vision’ can sometimes occur and become a problem due to the associated decrease of optical contrast that subsequently arises.1, 2, 3 It is also well known that even small ametropia, dry eye, or mild posterior capsule opacity (PCO) may have a role in these visual symptoms.4, 5 Therefore, strict management of these problems are recommended for eyes implanted with a diffractive IOL. However, most patients who experience diffractive IOL-associated hazy vision or waxy vision complain of these symptoms in the immediate postoperative period, possibly due to posterior capsule folds or the existence of residual epithelial cells as opposed to the proliferation of crystalline epithelial cells, as that proliferation does not occur until long after surgery. Thus, the residual epithelial cells or posterior capsule folds, as opposed to a postoperative proliferation of crystalline epithelial cells immediately after cataract surgery may have a role for cases in which PCO is theorized to be a trigger for those symptoms. However, in many cases the underlying cause of the postoperative hazy vision cannot be identified. And even in cases in which mild PCO is suspected to be a primary cause of the hazy vision, surgeons cannot be certain as to whether the yttrium aluminum garnet (YAG) laser posterior capsulotomy procedure will effectively decrease that haze until after the YAG procedure. Moreover, even though some cases ultimately require a replacement of diffractive IOLs with monofocal IOLs, it is very difficult to surgically exchange the IOLs after YAG capsulotomy.
In this study, we first evaluated the influence of mild opacity existing on the optical axis towards optical quality in a diffractive IOL implanted eye compared with a monofocal IOL implanted eye using an optical simulation in the laboratory setting. Next, we evaluated the clinical results of primary posterior continuous curvilinear capsulorhexis (PCCC) for the purpose of avoiding posterior capsule folds and cleaning up residual lens epithelial cells to avoid a decrease of contrast associated with the diffractive multifocal IOL implantation.
Materials and methods
Laboratory settings
An in-house produced model eye6 was prepared, and a charge-coupled device (CCD) camera (ARTCAM-150P; ARTRAY, Tokyo, Japan) was mounted to the eye. Test charts for visual acuity (VA) were set up 4 m in front of the model eye for distance VA, and at 50-cm and 40-cm in front of the model eye for near VA, and photographs were then taken through the model eye after it was alternately loaded with an AcrySof IQ monofocal IOL (SN60WF; Alcon Laboratories, Inc., Fort Worth, TX, USA; monofocal IOL eye) and a ReSTOR+3D diffractive IOL (SN6AD1; Alcon Laboratories; diffractive IOL eye) and under the following two conditions: (1) photos taken with no filter and (2) photos taken with an opaque filter (Foggy B filter; Kenko Tokina, Tokyo, Japan) for the simulation of mild PCO.
Clinical setting
The clinical evaluation involved 40 eyes of 20 patients (9 males and 11 females; age range: 41–75 years, mean age: 63.5 years) who underwent bilateral transplantation of the ReSTOR+3D IOL. Exclusion criteria included intraoperative complication and/or eyes with astigmatism >1.5 diopters (D), and patient screening was conducted until 20 cases were enrolled into the study. All cases underwent PCCC prior to IOL implantation in 1 eye (PCCC group), yet no PCCC prior to IOL implantation in the fellow eye (NCCC group), and the postoperative clinical results were then compared between the two groups. All procedures were approved by the Ethics Committee of Ouchi Eye Clinic, and informed consent was obtained from all subjects. This study was conducted in accordance with the tenets set forth in the Declaration of Helsinki.
Randomization
In all cases, the second operation was performed at 1 week after the first operation. Each eye was randomly assigned to either the PCCC group or the NCCC group via the envelope selection method. The data analyzer randomly picked and opened one of two envelopes (P- or N-lettered card inside) at the patient’s last visit prior to the first eye operation, and both the surgeon and patients were aware of which eye was to undergo PCCC immediately after assignment. Therefore, this study was not a blind study.
Surgical technique
A 2.2-mm, clear corneal incision was made by use of a 2.2-mm disposable steel knife (Slit knife 2.2DB; Alcon Laboratories). Phacoemulsification was performed by use of the Infiniti Vision System (Alcon Laboratories) with an attached 0.9-mm mini flare ABS phaco tip, 45° KELMAN, and ultra-sleeve (Alcon Laboratories). After removal of the cortex, the following procedures were conducted depending on the groups. In the PCCC group, after a viscoelastic agent was injected into the capsule bag, a posterior capsule tear was made using a 25-gauge needle and viscoelastic agent was injected between the posterior capsule and anterior vitreous membrane, followed by posterior capsulorhexis using capsular forceps. The IOL was then inserted into the capsular bag. In the NCCC group, the IOL was inserted immediately after injection of viscoelastic agent into the capsular bag post cortex removal. Slit-lamp examination of a PCCC eye at 1-day postoperative is shown in Figure 1.
Outcome measurement
In all eyes, uncorrected distance VA (UDVA), best-corrected distance VA (CDVA), uncorrected near VA (UNVA), best-corrected near VA (CNVA), respectively, low-contrast VA testing with 12.5 and 6% contrast, and contrast sensitivity tests were carried out at 1-day, 1-month, and 6-months postoperative. Optical coherence tomography (OCT) was also performed at 1-day and 6-months postoperative. Distance VA and low-contrast VA was measured with a VA system chart (SC-1600; NIDEK, Gamagori, Japan), and contrast sensitivity testing was conducted with a CSV-1000 (VectorVision, Greenville, OH, USA) test instrument under a mesopic non-glare condition. All patients completed a questionnaire pertaining to their overall opinion of the quality of distance and near vision (response scale: 1=very poor, 2=poor, 3=acceptable, 4=good, and 5=very good) at the 1-month postoperative visit.
The Mann–Whitney U-test was used to compare the preoperative baseline data and postoperative corneal astigmatism and spherical equivalent. The Wilcoxon signed-ranks test was used to compare the measurements of all the remaining postoperative data. The results are presented as mean±SEM unless otherwise noted. Any differences with a P-value of <0.05 were considered to be statistically significant.
Results
Laboratory settings
In the condition without the opaque filter, test charts for distance VA could be distinguished up to the five large Landolt rings, both in the monofocal IOL eye and the diffractive IOL eye (Figure 2a and b). In the diffractive IOL eye, photographs indicated clearer Landolt rings in the 50-cm and 40-cm test charts for near VA than in the monofocal IOL eye (Figure 2a and b). In the condition with the opaque filter, photographs both through the monofocal IOL eye and the diffractive IOL eye showed lower contrast compared with the nonfilter photos. However, decrease of contrast was greater in the diffractive IOL eye, with only three distinguishable large Landolt rings, while still five large Landolt rings could be distinguished in the monofocal IOL eye (Figure 2c and d).
Clinical setting
All enrolled eyes underwent the scheduled examinations. No significant difference was observed between the PCCC group and the NCCC group in preoperative baseline data including UDVA (0.49±0.34 and 0.48±0.41, respectively), CDVA (0.08±0.16 and 0.18±0.22, respectively), keratometric astigmatism (0.85±0.39D and 0.75±0.35D, respectively), spherical equivalent (−0.43±3.16D and −0.56±4.21D, respectively), and pupil size (3.76±0.82 and 3.61±0.81, respectively). In addition, no significant difference was observed in regard to postoperative corneal astigmatism (0.68±0.40D and 0.55±0.36D, respectively), spherical equivalent (−0.43±3.16D and −0.56±4.21D, respectively), and pupil size (3.70±0.82 mm and 3.61±0.81 mm, respectively) between the two groups (P=0.34, 0.36, and 0.35 respectively). No intraoperative or postoperative complication related to PCCC (ie, cystoid macular edema or retinal tears) was observed. YAG posterior capsulotomy was performed in one eye in the NCCC group owing to a strong complaint during the observation period.
Postoperative UDVA were −0.07±0.11, −0.05±0.18, and −0.06±0.11, respectively, in the PCCC group, and 0.005±0.18, −0.01±0.18, and −0.003± 0.10 in NCCC group, respectively, and PCCC group registered significant better at 1-day postoperative (Figure 3a). The CDVA findings were significantly better in PCCC group than in the NCCC group at 1-day and 6-month postoperative (−0.17±0.06, −0.12±0.08, and −0.15±0.07, respectively in the PCCC group, and −0.05±0.11, -0.07±0.1, and −0.07±0.1, respectively, in the NCCC group; Figure 3b). The PCCC group registered significantly better mean UNVA than did the NCCC group at all postoperative period (0.097±0.16, 0.098±0.09, and 0.12±0.17, respectively, in the PCCC group and 0.18±0.17, 0.18±0.19, and 0.22±0.14, respectively, in the NCCC group; Figure 3c). The mean CNVA findings were also better in PCCC group, with significance observed at 1-day and 6-month postoperative (−0.11±0.21, −0.07±0.09, and −0.08±0.09, respectively, in the PCCC group and −0.01±0.17, −0.02±0.08, and 0±0.08, respectively, in the NCCC group; Figure 3d). In low-contrast VA, both 12.5 and 6% contrast VA was found to be better in the PCCC group than in the NCCC group. There were significant differences at all postoperative periods in 12.5% low-contrast VA, and at 1-day and 6-month postoperative in the 6% low-contrast VA (Figure 4a and b).
The PCCC group registered better contrast sensitivity, with significant difference in 12 and 18 cycles per degree (cpd) at 1-day postoperative, and 12 cpd at 6-months postoperative (Figure 5).
The results of the patient questionnaire revealed that although all 20 patients (100%) rated their quality of vision as 4 or higher (good or very good) among the 5 items for their PCCC eye, 4 patients (20%) rated their quality of vision as 3 (acceptable) and 2 patients (10%) rated their quality of vision as 2 (poor) for their NCCC eye.
Discussion
In our laboratory setting, the diffractive IOL was more strongly affected by mild PCO than was the monofocal IOL in terms of visual quality. Moreover, better postoperative clinical results were observed and higher patient satisfaction was obtained when primary PCCC was performed at the time of surgery for removal of crystalline epithelial cells.
In many countries, the diffractive IOL is chosen for implantation due to the fact that it offers higher near addition and good reading VA, however, the hazy or waxy vision caused by the decrease of contrast sometimes becomes a problem.1, 2, 3 Moreover, mild ametropia, dry eye, and mild PCO are reported as major triggers for these visual symptoms; Woodward et al4 reported that PCO was observed in 54% of their hazy vision cases and deVries et al5 reported PCO in 67% of their hazy vision cases. However, patients usually complain of hazy vision from the very early postoperative period, so it is difficult to explain the underlying mechanism of the hazy vision with proliferation of crystalline lens epithelial cells. It is possible that a small number of remaining cells or posterior capsule folds become critical for visual quality from immediately after surgery in diffractive IOL implanted eyes.
In this study, we first investigated in the laboratory setting whether or not a diffractive IOL is more strongly affected by mild opacity on visual axis than is a monofocal IOL. Elgohary and Beckingsale7 reported that patients who undergo multifocal IOL implantation tend to be less tolerant of PCO-induced loss of visual function and tend to undergo YAG laser therapy for the treatment of early-stage PCO. Thus, even mild PCO, which seldom affects a monofocal IOL implanted eye, might lead to hazy vision in a diffractive IOL implanted eye. However, that theory has never been verified until now, even though it has been previously speculated.8 The results of our laboratory study ultimately verified that speculation.
Among the above-described triggers of hazy vision, a therapeutic effect can be simulated in regard to ametropia and dry eye using various temporal methods. However, the effect of the removal of PCO cannot be simulated in order for a surgeon to know whether or not mild PCO contributes to the hazy vision, and the efficacy of YAG laser treatment can only be known postoperatively. However, secondary IOL implantation into the capsule bag is very troublesome in cases following YAG posterior capsulotomy, though some cases do require the replacement of a diffractive IOL with a monofocal IOL. On this matter, opinions have been divided, as some reports state that YAG treatment should be done sooner because of neural adaptation,7, 8 whereas on the other hand, Woodward et al4 reported that surgeons should hold off on performing the YAG treatment until they are assured that the patient does not require an IOL exchange. Moreover, Vrijman et al9 reported that >0.5 D refractive shift was seen in 7% of diffractive IOL implantation cases that underwent YAG treatment, so it appears that this dilemma has yet to be resolved.
To address these problems, we next evaluated the effect of primary PCCC for diffractive IOL implantation in the clinical setting. Primary PCCC was first reported by Castaneda et al10 in 1992, and has now become a primary procedure in pediatric cataract surgery.11, 12, 13 Moreover, surgeons are increasingly introducing this procedure in cataract surgery for adult patients, and many reports have been published with good clinical results since 2003.14, 15, 16, 17, 18
In this study, we applied the PCCC technique for diffractive IOL Implantation. Performing primary PCCC eliminates the need to wonder if YAG laser treatment should be performed in cases of postoperative hazy vision, thus decreasing the surgeon’s stress in the postoperative follow-up. Moreover, this clinical study revealed that both distance and near VA registered significantly better in the PCCC group than in the NCCC, and that low-contrast VA and contrast sensitivity also registered better in the PCCC group. As can be seen in Figure 2b, PCO that might be remaining lens epithelial cells exists even at the very early postoperative period. Therefore, avoiding capsule folds or primary removal of lens epithelial cells on the visual axis might have provided an advantage in the PCCC group. Primary PCCC for monofocal IOL implantation has previously been reported and described for smaller optical axis opacity or low PCO rate,14, 15, 16, 17, 18 thus prompting the possibility that the potential optical loss associated with a diffractive IOL implanted eye would benefit strongly from PCCC.
In this study, no PCCC-related intraoperative or postoperative complications, such as cystoid macular edema or vitreous loss, were observed. Moreover, it was previously reported that PCCC had no effect on the blood-aqueous barrier,19 the blood–retinal barrier,20 or postoperative macular thickness.21 On the other hand, it is known that proliferation of lens epithelial cells can occur on the posterior surface of an IOL, and even after PCCC in some cases.17 Moreover, they can also proliferate with a foothold on the anterior vitreous membrane in young cases without anterior vitreous detachment. In this case series, even though no measures were taken to meet these situations, some cases revealed opacity on the posterior surface of the IOL. To address this matter, Menapace17, 22 reported the combined surgery of PCCC and posterior optic capture, and anterior vitrectomy has also been simultaneously used with PCCC in many pediatric cataract cases in which the strong proliferation of lens epithelial cells tends to occur.13 These additional procedures may provide a clue to advance the long-term results of primary PCCC combined diffractive IOL implantation.
It is important to note that this present study did have some limitations, as it was not performed as a blind study. Each patient was well aware as to which eye had undergone PCCC, and there is a possibility this knowledge did affect the answers in patient questionnaire. However, the protocol that was used is imperative for this kind of clinical study.
In conclusion, the implanted diffractive IOL was found to come under the influence of mild PCO compared with the implanted monofocal IOL. Primary PCCC to encourage transparency of the optical axis was found to be effective for postoperative visual function and patient satisfaction.
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I thank John Bush for reviewing the manuscript.
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Ouchi, M. Primary posterior continuous curvilinear capsulorhexis combined with diffractive multifocal intraocular lens implantation. Eye 30, 95–101 (2016). https://doi.org/10.1038/eye.2015.201
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DOI: https://doi.org/10.1038/eye.2015.201
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