Abstract
Objectives:
Congenital chylothorax is a rare disease and prognostic factors are key element in properly informing parents. This study aimed at determining the prenatal factors associated with neonatal survival in a cohort of liveborn infants with congenital chylothorax.
Study design:
Observational monocentric cohort study including all liveborn neonates consecutively admitted for congenital chylothorax.
Results:
Neonatal mortality was 32% (16/50). Prematurity (or birth weight), persistence of hydrops at birth and the absence of thoracoamniotic shunt procedure were significantly associated with mortality, whereas prenatal diagnosis of pleural effusion, side of pleural effusion, hydrops fetalis and amniodrainage were not. In case of prenatal diagnosis of hydrops fetalis, the reversal in utero of hydrops fetalis was significantly associated with survival (P=0.001). In case of thoracoamniotic shunting, the interval between thoracoamniotic shunting intervention and delivery was significantly longer for patients who survived (P=0.03).
Conclusions:
Thoracoamniotic shunting and reversal of hydrops significantly improves survival, whereas prematurity worsened outcome of liveborn infants with congenital chylothorax. Our data also suggest that the interval between thoracoamniotic shunting and birth appears to be crucial; the longer the interval, the more likely is the reversal of antenatal hydrops and neonatal survival.
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Acknowledgements
This study was supported by the ‘Association pour la Recherche et la Formation En Neonatologie (ARFEN)’, which provides technical assistance.
Author contributions
MD, AG and AL drafted the manuscript. They designed and participated in the study. They had access to all of the primary data and performed the statistical analyses. They participated in the review, revision and approval of the final manuscript. FL, JS, LSB, MN, ZA, NKD, EK, JFM and YV participated to the study and had access to all of the primary data. They critically revised the manuscript and provided significant scientific input. They participated in the review, revision and approval of the final manuscript.
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Supplementary Information accompanies the paper on the Journal of Perinatology website
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Dorsi, M., Giuseppi, A., Lesage, F. et al. Prenatal factors associated with neonatal survival of infants with congenital chylothorax. J Perinatol 38, 31–34 (2018). https://doi.org/10.1038/jp.2017.150
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DOI: https://doi.org/10.1038/jp.2017.150
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