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Comparison of haploidentical transplantation and single cord blood transplantation for myelofibrosis

Bone Marrow Transplantation volume 59, pages 705–707 (2024)Cite this article

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Allogeneic hematopoietic cell transplantation (HCT) is the only curative treatment for patients with myelofibrosis (MF) [1]. In the absence of an HLA-matched donor, HLA-haploidentical HCT (haplo-HCT) and unrelated cord blood transplantation (CBT) provide access to potentially life-saving therapies; this is because donors are rapidly available and the timing of transplantation is more flexible. However, the preferred choice between CBT or haplo-HCT for MF patients remains unclear.

This multicenter retrospective study analyzed clinical data obtained from the Unified Management Registry sponsored by the Japanese Society for Transplantation and Cellular Therapy (JSTCT). We compared the outcomes of 77 patients with MF who underwent haplo-HCT (n = 27) or CBT (n = 50) as first HCT between 2003 and 2019. The study was approved by the data-management committee of the (JSTCT), the Institutional Review Board of Osaka Metropolitan University, and all participating centers, and was conducted in accordance with the principles set down in the Declaration of Helsinki.

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Fig. 1: Comparison of outcomes in haplo versus CB recipients.

Data availability

The data of this study are not publicly available due to ethical restrictions that it exceeds the scope of the recipient/donor’s consent for research use in the registry.

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Authors and Affiliations

  1. Department of Hematology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan

    Kazuki Sakatoku & Hirohisa Nakamae

  2. Department of Hematology, Shiga University of Medical Science, Otsu, Japan

    Makoto Murata

  3. Department of Hematology, Kyoto University Hospital, Kyoto, Japan

    Yutaka Shimazu

  4. Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations, Toranomon Hospital, Tokyo, Japan

    Naoyuki Uchida

  5. Department of Hematology, Hyogo College of Medicine Hospital, Nishinomiya, Japan

    Satoshi Yoshihara

  6. Department of Hematology, Kitakyushu City Hospital Organization, Kitakyushu Municipal Medical Center, Kitakyushu, Japan

    Yasufumi Uehara

  7. Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

    Satoshi Takahashi

  8. Department of Hematology, Nagano Red Cross Hospital, Nagano, Japan

    Hikaru Kobayashi

  9. Department of Hematology, Nara Medical University Hospital, Nara, Japan

    Haruyuki Tanaka

  10. Department of Hematology, Imamura General Hospital, Kagoshima, Japan

    Nobuaki Nakano

  11. Japanese Red Cross Kanto-Koshinetsu Block Blood Center, Tokyo, Japan

    Fumihiko Ishimaru

  12. Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan

    Tatsuo Ichinohe

  13. Japanese Data Center for Hematopoietic Cell Transplantation, Nagakute, Japan

    Yoshiko Atsuta

  14. Department of Registry Science for Transplant and Cellular Therapy, Aichi Medical University School of Medicine, Nagakute, Japan

    Yoshiko Atsuta

  15. Department of Cell Processing and Transfusion, Department of Hematology/Oncology, Institute of Medical Science, the University of Tokyo, Tokyo, Japan

    Tokiko Nagamura-Inoue

Authors
  1. Kazuki Sakatoku
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  2. Makoto Murata
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  3. Yutaka Shimazu
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  4. Naoyuki Uchida
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  5. Satoshi Yoshihara
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  6. Yasufumi Uehara
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  9. Haruyuki Tanaka
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  10. Nobuaki Nakano
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  11. Fumihiko Ishimaru
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  12. Tatsuo Ichinohe
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  13. Yoshiko Atsuta
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  14. Tokiko Nagamura-Inoue
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  15. Hirohisa Nakamae
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Contributions

KS and HN designed the study, analyzed the data, interpreted the results, and wrote the manuscript. YS, MM, and TN interpreted the results, and reviewed and revised the manuscript. All the other authors contributed to data collection. All authors read and approved the final version.

Corresponding author

Correspondence to Kazuki Sakatoku.

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Competing interests

HN received research funding and honoraria from Novartis Pharma Co., Ltd. The other authors declare no competing interests.

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Sakatoku, K., Murata, M., Shimazu, Y. et al. Comparison of haploidentical transplantation and single cord blood transplantation for myelofibrosis. Bone Marrow Transplant 59, 705–707 (2024). https://doi.org/10.1038/s41409-024-02244-z

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  • DOI: https://doi.org/10.1038/s41409-024-02244-z

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