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References
Hao Y, O’Neill P, Naradikian MS, Scholz JL, Cancro MP. A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice. Blood. 2011;118:1294–304.
Cancro MP. Age-associated B cells. Annu Rev Immunol. 2020;38:315–40.
Wu C, Fu Q, Guo Q, Chen S, Goswami S, Sun S, et al. Lupus-associated atypical memory B cells are mTORC1-hyperactivated and functionally dysregulated. Ann Rheum Dis. 2019;78:1090–100.
Song W, Antao OQ, Condiff E, Sanchez GM, Chernova I, Zembrzuski K, et al. Development of Tbet- and CD11c-expressing B cells in a viral infection requires T follicular helper cells outside of germinal centers. Immunity. 2022;55:290–307.e5.
Wang S, Wang J, Kumar V, Karnell JL, Naiman B, Gross PS, et al. IL-21 drives expansion and plasma cell differentiation of autoreactive CD11c hi T-bet + B cells in SLE. Nat Commun. 2018;9:1758.
Du SW, Arkatkar T, Jacobs HM, Rawlings DJ, Jackson SW. Generation of functional murine CD11c+ age-associated B cells in the absence of B cell T-bet expression. Eur J Immunol. 2019;49:170–8.
Manni M, Gupta S, Ricker E, Chinenov Y, Park SH, Shi M, et al. Regulation of age-associated B cells by IRF5 in systemic autoimmunity. Nat Immunol. 2018;19:407.
Dai D, Gu S, Han X, Ding H, Jiang Y, Zhang X, et al. The transcription factor ZEB2 drives the formation of age-associated B cells. Science. 2024;383:413–21.
Xiao F, Rui K, Shi X, Wu H, Cai X, Lui KO, et al. Epigenetic regulation of B cells and its role in autoimmune pathogenesis. Cell Mol Immunol. 2022;19:1215–34.
Ma K, Li J, Wang X, Lin X, Du W, Yang X, et al. TLR4+CXCR4+ plasma cells drive nephritis development in systemic lupus erythematosus. Ann Rheum Dis. 2018;77:1498–506.
Acknowledgements
This work was supported by the National Natural Science Foundation of China (82071817, 82171793, 82371803), the Shenzhen Science and Technology Program (YCYJ20210324114602008), the Jiangsu Provincial Key Research and Development Program (BE2023758), the Hong Kong Research Grants Council (17113319, 17103821), the RGC Theme-based Research Scheme (TRS) (T12-703/19-R) and the Centre for Oncology and Immunology under the Health@InnoHK Initiative funded by the Innovation and Technology Commission, Hong Kong, China. The figure was drawn with BioRender with the permission of the publication license.
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Rui, K., Che, N., Ma, K. et al. Coming of age: the formation and function of age-associated B cells. Cell Mol Immunol 21, 311–312 (2024). https://doi.org/10.1038/s41423-024-01143-z
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DOI: https://doi.org/10.1038/s41423-024-01143-z