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The potentiation activity of β-lactam by phomoidrides and oxasetin against methicillin-resistant Staphylococcus aureus

The Journal of Antibiotics volume 77, pages 185–188 (2024)Cite this article

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Abstract

Antimicrobial resistance (AMR) causes a global health threat and enormous damage for humans. Among them, Methicillin-resistant Staphylococcus aureus (MRSA) resistant to first-line therapeutic β-lactam drugs such as meropenem (MEPM) is problematic. Therefore, we focus on combination drug therapy and have been seeking new potentiators of MEPM to combat MRSA. In this paper, we report the isolation of phomoidrides A–D and its new analog, phomoidride H along with a polyketide compound, oxasetin from the culture broth of Neovaginatispora clematidis FKI-8547 strain as potentiators of MEPM against MRSA.

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Acknowledgements

We are grateful to Distinguished Emeritus Professor Satoshi Ōmura (Kitasato University) for his helpful support and valuable suggestions. Further, we are grateful to Dr. K. Nagai, R. Seki, and N. Sato, School of Pharmacy, Kitasato University for the measurements of mass and NMR spectra. Also, we are grateful to Dr. K. Furuya for isolation of the fungal strain. This study was partially supported by the Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS), the Japan Agency for Medical Research & Development (AMED) under Grant Number JP21am0101096 and JP22ama121035. This research was also supported by AMED under Grant Number JP17ak0101053.

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Author notes

  1. These authors contributed equally: Masako Honsho, Aoi Kimishima, Akari Ikeda

Authors and Affiliations

  1. Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan

    Masako Honsho, Aoi Kimishima, Akari Ikeda, Masato Iwatsuki, Kenichi Nonaka, Hidehito Matsui, Hideaki Hanaki, Yukihiro Asami & Toshiaki Sunazuka

  2. Ōmura Satoshi Memorial Institute, Kitasato University, Tokyo, 108-8641, Japan

    Masako Honsho, Aoi Kimishima, Akari Ikeda, Masato Iwatsuki, Kenichi Nonaka, Hidehito Matsui, Hideaki Hanaki, Yukihiro Asami & Toshiaki Sunazuka

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  1. Masako Honsho
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  2. Aoi Kimishima
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Correspondence to Yukihiro Asami or Toshiaki Sunazuka.

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Honsho, M., Kimishima, A., Ikeda, A. et al. The potentiation activity of β-lactam by phomoidrides and oxasetin against methicillin-resistant Staphylococcus aureus. J Antibiot 77, 185–188 (2024). https://doi.org/10.1038/s41429-023-00691-2

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