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Discovery of antifungal secondary metabolites from an intestinal fungus Fusarium sp.

The Journal of Antibiotics volume 77, pages 193–198 (2024)Cite this article

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Abstract

Intestinal fungi, which are important parts of the gut microbiota, have the ability to produce specialized metabolites that significantly contribute to maintaining the balance of the gut microbiota and promoting the health of the host organism. In the present study, two new glycosides, including fusintespyrone A (1) and cerevisterolside A (4), as well as ten known compounds were isolated from the intestinal fungus Fusarium sp. LE06. The structures of the new compounds were elucidated by a combination of spectroscopic methods, such as mass spectrometry (MS) and nuclear magnetic resonance (NMR), along with chemical reactions and calculations of NMR and ECD spectra. Compounds 1–3 showed significant growth inhibition against Aspergillus fumigatus, Fusarium oxysporum, and Verticillium dahliae with MIC values in the range of 1.56–6.25 μg ml−1.

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Acknowledgements

Financial support of the National Key Research and Development Program of China (grant No. 2022YFA1304200) and the National Natural Science Foundation of China (grant Nos. 22177131 and 82073723) are gratefully acknowledged.

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Authors and Affiliations

  1. Key Laboratory of Structure-Based Drug Design & Discovery of Education, College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China

    Mingkai Zhang & Hongwei Liu

  2. State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, 100101, Beijing, China

    Mingkai Zhang, Baosong Chen, Huanqin Dai, Jingzu Sun, Hongwei Liu & Junjie Han

  3. Savaid Medical School, University of Chinese Academy of Sciences, 100049, Beijing, China

    Hongwei Liu

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  1. Mingkai Zhang
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Correspondence to Junjie Han.

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Zhang, M., Chen, B., Dai, H. et al. Discovery of antifungal secondary metabolites from an intestinal fungus Fusarium sp.. J Antibiot 77, 193–198 (2024). https://doi.org/10.1038/s41429-023-00692-1

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  • DOI: https://doi.org/10.1038/s41429-023-00692-1

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