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Benastatin K, a chlorinated benastatin-related antibiotic from Streptomyces sp. HGTA384

The Journal of Antibiotics (2024)Cite this article

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Abstract

Benastatin K (1), a new chlorinated benastatin derivative, was isolated from the culture broth of the actinomycete Streptomyces sp. HGTA384. The structure of 1 was determined on the basis of spectroscopic analysis, including 1D and 2D NMR, as well as HRESI-MS, UV and IR, and comparison with data reported in the literature. Compound 1 and benastatins A and B exhibited inhibitory activity against Micrococcus luteus (MIC 7.8, 31.3, and 3.9 μM, respectively), and IgE-mediated β-hexosaminidase release in RBL-2H3 cells with IC50 values of 42, 79, and 19 μM, respectively.

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Acknowledgements

This work was supported by JSPS KAKENHI Grant Number JP19K07135 (TK) and the Useful and Unique Natural Products for Drug Discovery and Development (UpRod) Program for Building Regional Innovation Ecosystems at Kumamoto University, Japan. The authors would like to thank Dr. Hari Prasad Devkota, Kumamoto University, for his assistance in improving the English of the manuscript.

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Authors and Affiliations

  1. Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto, 862-0973, Japan

    Teppei Kawahara & Mikiyo Wada

  2. Kumamoto Industrial Research Institute, 3-11-38 Higashi-machi, Higashi-ku, Kumamoto, 862-0901, Japan

    Kanako Saita

  3. School of Pharmacy, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto, 862-0973, Japan

    Rika Iwamoto

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  1. Teppei Kawahara
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Correspondence to Teppei Kawahara.

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Kawahara, T., Saita, K., Iwamoto, R. et al. Benastatin K, a chlorinated benastatin-related antibiotic from Streptomyces sp. HGTA384. J Antibiot (2024). https://doi.org/10.1038/s41429-024-00727-1

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  • DOI: https://doi.org/10.1038/s41429-024-00727-1

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