Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Brief Communication
  • Published:

Drug-induced macular oedema

Eye (2024)Cite this article

Subjects

A comprehensive review of the literature was undertaken, focusing on macular oedema induced by drug usage. The findings delineate two distinct categories of macular oedema: one induced by drugs and the other precipitated by diseases. It was observed that the symptoms associated with drug-induced macular oedema could be alleviated by moderating the dosage or frequency of the drug intake. However, macular oedema resulting from diseases, such as diabetes, may not exhibit similar improvements.

Li et al. reported that a 38-year-old Chinese woman with secondary progressive multiple sclerosis experienced limb numbness and leg fatigue [1]. After 4 months of siponimod treatment, she developed mild macular oedema. The condition resolved upon discontinuing the medication and didn’t recur when the treatment was resumed [1].

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Li Q, Jing LJ, Li Y, Jia Y. Macular edema after siponimod treatment for multiple sclerosis: a case report and literature review. BMC Neurol. 2023;23:286. https://doi.org/10.1186/s12883-023-03333-0.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Khan AA, Gutlapalli SD, Sohail M, Patel P, Midha S, Shukla S, et al. Fingolimod-associated macular edema in the treatment of multiple sclerosis. Cureus. 2023;15:e41520. https://doi.org/10.7759/cureus.41520.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Ahmad R, Mehta H. The ocular adverse effects of oral drugs. Aust Prescr. 2021;44:129–36. https://doi.org/10.18773/austprescr.2021.028.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Sinnathamby ES, Urban BT, Clark RA, Roberts LT, De Witt AJ, Wenger DM, et al. Etiology of drug-induced edema: a review of dihydropyridine, thiazolidinedione, and other medications causing edema. Cureus. 2024;16:e53400. https://doi.org/10.7759/cureus.53400.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Faculty of Data Science, Musashino University, 3-3-3 Ariake Koto-ku, Tokyo, 135-8181, Japan

    Yoshiyasu Takefuji

Authors
  1. Yoshiyasu Takefuji
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yoshiyasu Takefuji.

Ethics declarations

Competing interests

The author declares no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Takefuji, Y. Drug-induced macular oedema. Eye (2024). https://doi.org/10.1038/s41433-024-03117-x

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1038/s41433-024-03117-x

Search

Advanced search

Quick links