Several studies indicate that, in individuals infected with herpes simplex virus and/or varicella zoster virus, antiviral therapy reduces the subsequent risk of Alzheimer disease and other types of dementia. As highlighted in this article, the preventative potential of antiviral therapy would probably be maximized by treating asymptomatic as well as symptomatic infected individuals.
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Dementia, infections and vaccines: 30 years of controversy
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References
Tsai, M. C. et al. Increased risk of dementia following herpes zoster ophthalmicus. PLoS One 12, e0188490 (2017).
Tzeng, N. S. et al. Anti-herpetic medications and reduced risk of dementia in patients with herpes simplex virus infections — a nationwide, population-based cohort study in Taiwan. Neurotherapeutics 15, 417–429 (2018).
Chen, V. C. et al. Herpes zoster and dementia: a nationwide population-based cohort study. J. Clin. Psychiatry 79, 16m11312 (2018).
Itzhaki, R. F. et al. Herpes simplex virus type 1 in brain and risk of Alzheimer’s disease. Lancet 349, 241–244 (1997).
Itzhaki, R. F. Overwhelming evidence for a major role for herpes simplex virus type 1 (HSV1) in Alzheimer’s disease (AD); underwhelming evidence against. Vaccines 9, 679 (2021).
Bae, S. et al. Association of herpes zoster with dementia and effect of antiviral therapy on dementia: a population-based cohort study. Eur. Arch. Psychiatry Clin. Neurosci. 271, 987–997 (2021).
Schnier, C. et al. Antiherpetic medication and incident dementia: observational cohort studies in four countries. Eur. J. Neurol. 28, 1840–1848 (2021).
Lopatko Lindman, K. et al. Herpesvirus infections, antiviral treatment, and the risk of dementia — a registry-based cohort study in Sweden. Alzheimers Dement. 7, e12119 (2021).
Young-Xu, Y. et al. Symptomatic herpes simplex virus infection and risk of dementia in US veterans: a cohort study. Neurotherapeutics https://doi.org/10.1007/s13311-021-01084-9 (2021).
Hemmingsson, E. S. et al. Antiviral treatment associated with reduced risk of clinical Alzheimer’s disease — a nested case-control study. Alzheimers Dement. 7, e12187 (2021).
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Itzhaki, R.F. Does antiherpetic antiviral therapy reduce the risk of dementia?. Nat Rev Neurol 18, 63–64 (2022). https://doi.org/10.1038/s41582-021-00596-4
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DOI: https://doi.org/10.1038/s41582-021-00596-4
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Dementia, infections and vaccines: 30 years of controversy
Aging Clinical and Experimental Research (2023)