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Volume 20 Issue 5, May 2024

Stimulating brain circuits, inspired by the Review on p259.

Cover design: Philip Patenall

Q&A

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Research Highlights

  • New data recently reported at the ACTRIMS Forum add to growing evidence of an aetiological role for Epstein–Barr virus infection in multiple sclerosis.

    • Heather Wood
    Research Highlight
  • Findings of phase III trials of the Bruton’s tyrosine kinase inhibitor evobrutinib in patients with relapsing multiple sclerosis were recently presented at the ACTRIMS Forum.

    • Heather Wood
    Research Highlight
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News & Views

  • Success in a trial of low-intensity ultrasound combined with an amyloid-β antibody represents a major stride towards integrating pharmacological and nonpharmacological approaches to reduce the amyloid-β load in patients with mild Alzheimer disease. This trial also highlights the potential of therapeutic ultrasound modalities to combat neurodegenerative diseases.

    • Jürgen Götz
    • Pranesh Padmanabhan
    News & Views
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Reviews

  • Various neurostimulation techniques are being explored for the treatment of physical impairments in people with stroke. This Review summarizes our current knowledge of the techniques that are now in clinical use or have reached the stage of pivotal trials alongside emerging techniques and highlights the need for further studies.

    • Jesse Dawson
    • Azmil H. Abdul-Rahim
    • Teresa J. Kimberley
    Review Article
  • Neurofilaments have been validated as specific body fluid biomarkers of neuro-axonal injury. In this Review, Khalil and colleagues provide an update on the structure and function of neurofilaments, analytical approaches and challenges in different clinical contexts, and progress towards clinical application of neurofilaments as a biomarker in various neurological disorders.

    • Michael Khalil
    • Charlotte E. Teunissen
    • Jens Kuhle
    Review Article
  • In this Review, the authors discuss the unique neurological health disparities faced by sexual and gender minority (LGBT+) people. The Review presents clinical considerations alongside language and practice recommendations to promote inclusive care, and highlights the gaps in need of further research.

    • Salvatore Giovanni Volpe
    • Joya Ahmad
    • Nicole Rosendale
    Review Article
  • Post-traumatic epilepsy is a major driver of disability associated with traumatic brain injury. This article reviews the epidemiology and clinical features of post-traumatic epilepsy and discusses how an understanding of the underlying epileptogenic mechanisms might inform the development of anti-epileptogenic medications.

    • Matthew Pease
    • Kunal Gupta
    • James F. Castellano
    Review Article
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