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Chen et al. reply

Nature volume 562, pages E19–E20 (2018)Cite this article

REPLYING TO B. P. Oestringer et al. Nature 562, https://doi.org/10.1038/s41586-018-0561-9 (2018)

In the accompanying Comment1, Oestringer et al. argue that the p7 protein from hepatitis C virus, which we used to determine the p7 oligomeric structure in dodecylphosphocholine (DPC) micelles2, is monomeric. Here we show, with direct experimental evidence, that their assertion is wrong.

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Fig. 1: Mixed NOEs and negative controls.

References

  1. Oestringer, B. P. et al. Re-evaluating the p7 viroporin structure. Nature 562, http://doi.org/10.1038/s41586-018-0561-9 (2018).

  2. OuYang, B. et al. Unusual architecture of the p7 channel from hepatitis C virus. Nature 498, 521–525 (2013).

    Article  ADS  CAS  Google Scholar 

  3. Chen, W. et al. The unusual transmembrane partition of the hexameric channel of the hepatitis C virus. Structure 26, 627–634 (2018).

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA

    Wen Chen & James J. Chou

  2. State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Science Research Center, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China

    Bo OuYang

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  1. Wen Chen
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  2. Bo OuYang
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  3. James J. Chou
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Contributions

W.C., B.O. and J.J.C. wrote the response.

Corresponding author

Correspondence to James J. Chou.

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Chen, W., OuYang, B. & Chou, J.J. Chen et al. reply. Nature 562, E19–E20 (2018). https://doi.org/10.1038/s41586-018-0562-8

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