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Reply to: ‘Do all norepinephrine surges disrupt sleep?’

Nature Neuroscience volume 26, pages 957–958 (2023)Cite this article

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The Original Article was published on 20 April 2023

replying to: A. Lüthi et al. Nature Neuroscience https://doi.org/10.1038/s41593-023-01313-8 (2023).

We recently published findings showing that infraslow oscillations of norepinephrine (NE) during sleep—driven by activity bursts of locus coeruleus—is an important regulator of sleep microarchitecture1. Specifically, NE oscillations control the transition between spindle-rich non-rapid eye movement (NREM) sleep segments and microarousals.

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Fig. 1: NE increases are associated with EEG desynchronization.

References

  1. Kjaerby, C. et al. Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine. Nat. Neurosci. 25, 1059–1070 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Lüthi, A., Franken, P., Fulda, S., Siclari, F. & van Someren, E. J. W. Do all norepinephrine surges disrupt sleep? Nat. Neurosci. https://doi.org/10.1038/s41593-023-01313-8 (2023).

  3. Aston-Jones, G. & Bloom, F. E. Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep–waking cycle. J. Neurosci. 1, 876–886 (1981).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Carter, M. E. et al. Tuning arousal with optogenetic modulation of locus coeruleus neurons. Nat. Neurosci. 13, 1526–1533 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Halász, P., Terzano, M., Parrino, L. & Bódizs, R. The nature of arousal in sleep. J. Sleep Res. 13, 1–23 (2004).

    Article  PubMed  Google Scholar 

  6. EEG arousals: scoring rules and examples: a preliminary report from the Sleep Disorders Atlas Task Force of the American Sleep Disorders Association. Sleep 15, 173–184 (1992).

  7. Lecci, S. et al. Coordinated infraslow neural and cardiac oscillations mark fragility and offline periods in mammalian sleep. Sci. Adv. 3, e1602026 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Osorio-Forero, A. et al. Noradrenergic circuit control of non-REM sleep substates. Curr. Biol. 31, 5009–5023 (2021).

    Article  CAS  PubMed  Google Scholar 

  9. Fultz, N. E. et al. Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep. Science 366, 628–631 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Picchioni, D. et al. Autonomic arousals contribute to brain fluid pulsations during sleep. Neuroimage 249, 118888 (2022).

    Article  PubMed  Google Scholar 

  11. Näsi, T., Virtanen, J., Toppila, J., Salmi, T. & Ilmoniemi, R. J. Cyclic alternating pattern is associated with cerebral hemodynamic variation: a near-infrared spectroscopy study of sleep in healthy humans. PLoS ONE 7, e46899 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  12. Kokkinos, V. et al. A hemodynamic network involving the insula, the cingulate, and the basal forebrain correlates with EEG synchronization phases of sleep instability. Sleep 42, zsy259 (2019).

    Article  PubMed  Google Scholar 

  13. Bojarskaite, L. et al. Sleep cycle-dependent vascular dynamics in male mice and the predicted effects on perivascular cerebrospinal fluid flow and solute transport. Nat. Commun. 14, 953 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Mestre, H. et al. Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension. Nat. Commun. 9, 4878 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  15. Bonnet, M. H. & Arand, D. L. EEG arousal norms by age. J. Clin. Sleep Med. 3, 271–274 (2007).

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Copenhagen, Copenhagen, Denmark

    Celia Kjaerby, Mie Andersen, Natalie Hauglund, Verena Untiet, Camilla Dall, Hajime Hirase & Maiken Nedergaard

  2. Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY, USA

    Fengfei Ding, Hajime Hirase & Maiken Nedergaard

Authors
  1. Celia Kjaerby
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  2. Mie Andersen
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  3. Natalie Hauglund
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  4. Verena Untiet
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  5. Camilla Dall
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  6. Fengfei Ding
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  7. Hajime Hirase
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Contributions

C.K., M.A., H.H. and M.N. wrote and revised the reply.

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Correspondence to Celia Kjaerby or Maiken Nedergaard.

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Kjaerby, C., Andersen, M., Hauglund, N. et al. Reply to: ‘Do all norepinephrine surges disrupt sleep?’. Nat Neurosci 26, 957–958 (2023). https://doi.org/10.1038/s41593-023-01314-7

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