Mechanisms and management of metabolic dysfunction-associated steatotic liver disease

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is rapidly emerging as a global heath challenge. This intricate condition, characterized by the abnormal accumulation of fat in the liver due to metabolic imbalances like insulin resistance and obesity, spans a spectrum of diseases from isolated lipid accumulation or steatosis (metabolic dysfunction-associated steatotic liver, MASL) to its active inflammatory form, metabolic dysfunction-associated steatohepatitis (MASH). MASLD presents a significant risk of progressing to severe stages, with individuals potentially transitioning from MASL to MASH, characterized by inflammation and liver cell damage. Despite its increasing prevalence and far-reaching implications, MASLD has become a primary indication for liver transplantation and a significant etiological factor for liver cancer. This underscores the need for a profound understanding of the intricate mechanisms governing the interplay between metabolic dysfunction, hepatic steatosis, and the progression towards MASH–an understanding imperative for the development of effective management strategies.

This research collection is dedicated to a comprehensive exploration of MASLD, recognizing its spectrum from MASL to MASH. The primary focus is on unraveling the molecular and cellular intricacies underlying the disease and exploring innovative approaches for its effective management.

We warmly invite contributions encompassing original clinical and basic research articles, meta-analyses, and reviews. Topics of interest include, but are not limited to:

• Interactions between metabolic dysfunction and hepatic steatosis:
  Delving into the dynamic connections shaping the progression of MASLD along its spectrum.
• Cellular and molecular mechanisms of disease progression:
  Exploring the nuanced pathways and mechanisms that drive the evolution of MASLD.
• Innovative therapeutic approaches:
  Showcasing cutting-edge research on novel interventions, pharmaceutical developments, and holistic strategies aimed at effectively managing MASLD.

This Collection supports and amplifies research related to SDG 3.