Milestone 

Nature Milestones in Antisense RNA

The discovery of antisense RNA phenomena has profoundly altered our understanding of gene regulation and revolutionized the way biological research is conducted. The potency, specificity and ease of synthesis of antisense RNAs have made them ubiquitous and therapeutically-attractive agents in biomedical research.

This Milestone charts the history of antisense RNA breakthroughs on an interactive Timeline and provides key articles and relevant reviews from Nature Research journals. We hope you will enjoy the read!

This Milestone is editorially independent, produced with financial support from a third party. About this content.

Coordinating Editors: Alfredo Sansone, Anke Sparmann, Eytan Zlotorynski

Copy Editor: Chloe Rees-Spear
Editorial Production: Simon Fenwick
Print Production: Susan Gray
Web Production: Nick Bruni
Design & Web Development: Jason Mischka
Marketing: Nicole Jackson
Publisher: Tim Geach
Editor-in-Chief, Nature Publications: Magdalena Skipper 
Sponsorship: David Bagshaw, Claudia Danci

We gratefully acknowledge scientific advice from:

Julius Brennecke 
Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter, Austria

Anastasia Khvorova
RNA Therapeutics Institute, University of Massachusetts Medical School, USA

Judy Lieberman 
Boston Children’s Hospital and Department of Pediatrics, Harvard Medical School, USA

Frank Slack
Department of Pathology, BIDMC Cancer Center, Harvard Medical School, USA

Bruce Sullenger
Department of Surgery, Duke University Medical Center, USA

Contributing journals

Nature Communications
Nature Reviews Molecular Cell Biology
Nature Structural & Molecular Biology
Nature Protocols
Nature Plants
Communications Biology
Nature Reviews Cross-Journal Team