Metabolic control of aging and metabolism
- Submission status
- Closed
- Submission deadline
A range of metabolic alterations accumulate over time often setting off the path to compromised biological fitness and disease. On the other hand, genetic loci linked to exceptional longevity in model organisms and humans are core components of cellular metabolism. The hypercaloric “western” diet dominated by refined sugars and excess fats commonly disturbs metabolic homeostasis driving age-associated pathologies and accelerated aging. Conversely, lifespan-extending interventions including caloric restriction and modulation of nutrient sensing cascades prove beneficial via their pleiotropic effects on metabolism. Each of the hallmarks of aging can be traced to metabolic perturbations meaning that optimising an individual’s metabolic fitness are promising strategies to extend human healthspan.
This collection aims to cover a broad range of themes linking metabolism and lifespan. With the aim to understand the aging process through the lens of metabolism, we welcome studies interrogating basic cellular and genetic mechanisms as well as complex interactions between metabolism and nutrition, lifestyle and environment. The collection seeks to unveil metabolic influences on aging in various systems including in vitro, transgenic models and species with diverse lifespans. The possibility of optimising metabolic fitness via metabolic interventions aimed at promoting healthy aging will also be addressed.
The topics include, but are not limited to:
- Metabolic mechanisms underlying ageing and age-associated pathologies
- Models to study the link between metabolism and the aging process
- Genetic loci contributing to aging or extended lifespan
- Environmental and lifestyle factors attenuating or accelerating the ageing process
- Metabolic disturbance within the hallmarks of aging
- Metabolic interventions that improve longevity
Editors
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Jane Reznick, PhD
CECAD Research Center/ University Hospital Cologne, Cologne, Germany
All articles have undergone npj Metabolic Health and Disease's standard peer review process and have been subject to all the journal’s standard policies. This includes the journal’s policy on competing interests. The Editors declare no competing interests with the submissions which they have handled through the peer review process. The peer review of any submissions for which the Editors have competing interests is handled by another Editorial Board Member who has no competing interests.
If accepted for publication, an article processing charge applies (with standard waiver policy). If your institution or country has an open access agreement with Springer Nature, you may publish your article OA at no cost or in some cases with the costs partially funded (see details here).
All Collections are open for submissions from all authors – and not by invitation only – on the condition that the manuscripts fall within the scope of the Collection and of npj Metabolic Health and Disease more generally.
Manuscripts submitted to an open Collection may be considered unsuitable for inclusion, particularly if they fall outside the scope of the Collection. In such cases, the authors will be notified by the editorial office and their manuscript can be considered as a regular npj Metabolic Health and Disease submission.
npj Metabolic Health and Disease’s in-house editors reserve the right to assume responsibility for the management of a Collection at any stage.
