Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
The cover shows unusual features of papillary renal neoplasm with reverse polarity, including cystic neoplasm filled with eosinophilic proteinaceous material containing loose hemosiderin-laden macrophages and cellular debris, edematous and expanded fibrovascular cores containing chronic inflammatory infiltrates, focal clear cell changes, and hobnail conformation. For more information, see the paper by Al-Obaidy et al, p. 1279, this issue.